Evidence map›Paper›PMID 27027416›Full record

Trial reportSurgical infections2016

Obesity Is Not Associated with Antimicrobial Treatment Failure for Intra-Abdominal Infection.

Zachary C Dietch, Therese M Duane, Charles H Cook, Patrick J O'Neill, Reza Askari, Lena M Napolitano, Nicholas Namias, Christopher M Watson, Daniel L Dent, Brandy L Edwards and 5 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgical infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zachary C Dietch1 Department of Surgery, The University of Virginia Health System , Charlottesville, Virginia.
Therese M Duane3 Department of Surgery, Virginia Commonwealth University , Richmond, Virginia.
Charles H Cook4 Department of Surgery, Beth Israel Deaconess Medical Center , Boston, Massachusetts.
Patrick J O'Neill5 Department of Surgery, Maricopa Integrated Health System , Phoenix, Arizona.
Reza Askari6 Department of Surgery, Brigham and Women's Hospital , Boston, Massachusetts.
Lena M Napolitano7 Department of Surgery, University of Michigan , Ann Arbor, Michigan.
Nicholas Namias8 Department of Surgery, University of Miami Miller School of Medicine , Miami, Florida.
Christopher M Watson9 Department of Surgery, University of South Carolina , Columbia, South Carolina.
Daniel L Dent10 Department of Surgery, University of Texas Health Science Center at San Antonio , San Antonio, Texas.
Brandy L Edwards1 Department of Surgery, The University of Virginia Health System , Charlottesville, Virginia.
Puja M Shah1 Department of Surgery, The University of Virginia Health System , Charlottesville, Virginia.
Christopher A Guidry1 Department of Surgery, The University of Virginia Health System , Charlottesville, Virginia.
Stephen W Davies1 Department of Surgery, The University of Virginia Health System , Charlottesville, Virginia.
Rhett N Willis1 Department of Surgery, The University of Virginia Health System , Charlottesville, Virginia.
Robert G Sawyer1 Department of Surgery, The University of Virginia Health System , Charlottesville, Virginia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity and commonly associated comorbidities are known risk factors for the development of infections. However, the intensity and duration of antimicrobial treatment are rarely conditioned on body mass index (BMI). In particular, the influence of obesity on failure of antimicrobial treatment for intra-abdominal infection (IAI) remains unknown. We hypothesized that obesity is associated with recurrent infectious complications in patients treated for IAI.

methodsFive hundred eighteen patients randomized to treatment in the Surgical Infection Society Study to Optimize Peritoneal Infection Therapy (STOP-IT) trial were evaluated. Patients were stratified by obese (BMI ≥30) versus non-obese (BMI≥30) status. Descriptive comparisons were performed using Chi-square test, Fisher exact test, or Wilcoxon rank-sum tests as appropriate. Multivariable logistic regression using a priori selected variables was performed to assess the independent association between obesity and treatment failure in patients with IAI.

resultsOverall, 198 (38.3%) of patients were obese (BMI ≥30) versus 319 (61.7%) who were non-obese. Mean antibiotic d and total hospital d were similar between both groups. Unadjusted outcomes of surgical site infection (9.1% vs. 6.9%, p = 0.36), recurrent intra-abdominal infection (16.2% vs. 13.8, p = 0.46), death (1.0% vs. 0.9%, p = 1.0), and a composite of all complications (25.3% vs. 19.8%, p = 0.14) were also similar between both groups. After controlling for appropriate demographics, comorbidities, severity of illness, treatment group, and duration of antimicrobial therapy, obesity was not independently associated with treatment failure (c-statistic: 0.64).

conclusionsObesity is not associated with antimicrobial treatment failure among patients with IAI. These results suggest that obesity may not independently influence the need for longer duration of antimicrobial therapy in treatment of IAI versus non-obese patients.

Indexed as

AdultAgedAnti-Infective AgentsBody Mass IndexDrug Administration ScheduleHumansIntraabdominal InfectionsMiddle AgedObesityRecurrenceRegression AnalysisTreatment FailureAnti-Infective Agents

Identifiers

PMID27027416
PMCPMC4960476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.