ArticleOncotarget2016
Estimation of the risk of secondary malignancy arising from whole-breast irradiation: comparison of five radiotherapy modalities, including TomoHDA.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Dosimetric and Secondary Cancer Risk Comparison after Radiation Therapy for Breast Cancer with Three-Dimensional Conformal Radiotherapy, and Helical Tomotherapy.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Dose-volume histogram-based comparison of conventional and hypofractionated radiotherapy: lifetime attributable risk estimation in Indian breast carcinoma patients.Radiological physics and technology · 2025Article
- Recent advances progress in radiotherapy for breast cancer after breast-conserving surgery: a review.Frontiers in oncology · 2023Review
- Pulmonary toxicity of craniospinal irradiation using helical tomotherapy.Scientific reports · 2022Article
- Comparison of Breast Cancer Radiotherapy Techniques Regarding Secondary Cancer Risk and Normal Tissue Complication Probability - Modelling and Measurements Using a 3D-Printed Phantom.Frontiers in oncology · 2022Article
- Dosimetric comparison of incidental axillary irradiation between three-dimensional conformal and volumetric modulated arc techniques for breast cancer.Molecular and clinical oncology · 2020Article
- Secondary cancer risk after radiation therapy for breast cancer with different radiotherapy techniques.Scientific reports · 2020Article
- Secondary cancer risk after whole-breast radiation therapy: field-in-field versus intensity modulated radiation therapy versus volumetric modulated arc therapy.The British journal of radiology · 2019Article
- Estimation of radiotherapy modalities for patients with stage I-II nasal natural killer T-Cell lymphoma.Cancer management and research · 2019Article
- Exposure of remote organs and associated cancer risks from tangential and multi-field breast cancer radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2019Article
- Comparison of semiautomated tangential VMAT with 3DCRT for breast or chest wall and regional nodes.Journal of applied clinical medical physics · 2018Article
- Left-sided breast cancer and risks of secondary lung cancer and ischemic heart disease : Effects of modern radiotherapy techniques.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018Article
- Critical appraisal of the role of volumetric modulated arc therapy in the radiation therapy management of breast cancer.Radiation oncology (London, England) · 2017Review
- Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features.Oncotarget · 2016Article
- Comparison of conventional and advanced radiotherapy techniques for left-sided breast cancer after breast conserving surgery.Medical dosimetry : official journal of the American Association of Medical DosimetristsArticle
- Estimation of the Thyroid Secondary Cancer Risk on the Patient of Standard Breast External Beam Radiotherapy.Journal of medical signals and sensorsArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk of secondary cancer from radiation treatment remains a concern for long-term breast cancer survivors, especially those treated with radiation at the age younger than 45 years. Treatment modalities optimally maximize the dose delivery to the tumor while minimizing radiation doses to neighboring organs, which can lead to secondary cancers. A new TomoTherapy treatment machine, TomoHDATM, can treat an entire breast with two static but intensity-modulated beams in a slice-by-slice fashion. This feature could reduce scattered and leakage radiation doses. We compared the plan quality and lifetime attributable risk (LAR) of a second malignancy among five treatment modalities: three-dimensional conformal radiation therapy, field-in-field forward-planned intensity-modulated radiation therapy, inverse-planned intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy, and TomoDirect mode on the TomoHDA system. Ten breast cancer patients were selected for retrospective analysis. Organ equivalent doses, plan characteristics, and LARs were compared. Out-of-field organ doses were measured with radio-photoluminescence glass dosimeters. Although the IMRT plan provided overall better plan quality, including the lowest probability of pneumonitis, it caused the second highest LAR. The TomoTherapy plan provided plan quality comparable to the IMRT plan and posed the lowest total LAR to neighboring organs. Therefore, it can be a better treatment modality for younger patients who have a longer life expectancy.
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