ReviewSpringerPlus2016
Review of evolving etiologies, implications and treatment strategies for the superior vena cava syndrome.
Review in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 150 citations in OpenAlex.
- Covered Endovascular Reconstruction of the Anonymous Confluence (CERAC): a technical note describing a confluence-preserving endovascular technique.CVIR endovascular · 2026Article
- The Surgical Outcomes of Brachiocephalic Vein Transection Versus Reconstruction for Locally Advanced Thymic Epithelial Tumors.Annals of surgical oncology · 2026Article
- Superior vena cava-to-inferior vena cava bridging stent technique for cavo-atrial junction stenosis: a case series.European heart journal. Case reports · 2026Article
- A case of esophageal cancer with superior vena cava syndrome treated with chemotherapy via a central venous port placed by translumbar approach.Clinical journal of gastroenterology · 2025Article
- Dilated thoracoabdominal and epigastric veins in a hemodialysis patient with SVC occlusion: case report and literature review.Frontiers in cardiovascular medicine · 2025Article
- A Comprehensive Review of Catheter-Related Thrombosis.Journal of clinical medicine · 2024Review
- Inferior and Superior Vena Cava Reconstruction.Cardiovascular and interventional radiology · 2024Review
- Superior and inferior vena cava syndrome caused by a rare lung cancer: A case report.Clinical case reports · 2024Article
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- Surgical resection of an intraluminal tumor in the azygos vein with an unknown primary site causing superior vena cava syndrome.Thoracic cancer · 2024Article
- Risk factors for hypotension in patients with hemodialysis-associated superior vena cava syndrome.Journal of vascular surgery. Venous and lymphatic disorders · 2024Article
- Endovascular interventions in cancer patients with compromise of the mediastinal vasculature: a review.Mediastinum (Hong Kong, China) · 2024Review
- Inpatient outcomes for lung cancer patients presenting with superior vena cava thrombosis.Proceedings (Baylor University. Medical Center) · 2024Article
- Bedside physician led US-guided supra-clavicular lymph node biopsy and ROSE (rapid on-site evaluation): SVC obstruction swift management in lung cancer.Respiratory medicine case reports · 2024Article
- Superior vena cava syndrome induced by lung hyperinflation in chronic obstructive pulmonary disease: a case report.Journal of medical case reports · 2023Article
- Outcomes in patients managed with endovascular stent for malignant superior vena cava syndrome.Surgery open science · 2023Article
- A Case of a Constricted Vessel: The Impact of Acute Myeloid Leukemia on the Superior Vena Cava.Cureus · 2023Article
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- Thoracic central venous occlusion from the interventional radiology perspective.Cardiovascular diagnosis and therapy · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Superior vena cava syndrome (SVCS) is a relatively common sequela of mediastinal malignancies and may cause significant patient distress. SVCS is a medical emergency if associated with laryngeal or cerebral edema. The etiologies and management of SVCS have evolved over time. Non-malignant SVCS is typically caused by infectious etiologies or by thrombus in the superior vena cava and can be managed with antibiotics or anti-coagulation therapy, respectively. Radiation therapy (RT) has long been a mainstay of treatment of malignant SVCS. Chemotherapy has also been used to manage SVCS. In the past 20 years, percutaneous stenting of the superior vena cava has emerged as a viable option for SVCS symptom palliation. RT and chemotherapy are still the only modalities that can provide curative treatment for underlying malignant etiologies of SVCS. The first experiences with treating SVCS with RT were reported in the 1970's, and several advances in RT delivery have subsequently occurred. Hypo-fractionated RT has the potential to be a more convenient therapy for patients and may provide equal or superior control of underlying malignancies. RT may be combined with stenting and/or chemotherapy to provide both immediate symptom palliation and long-term disease control. Clinicians should tailor therapy on a case-by-case basis. Multi-disciplinary care will maximize treatment expediency and efficacy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.