Evidence map›Paper›PMID 27026620›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2016

Developing knowledge resources to support precision medicine: principles from the Clinical Pharmacogenetics Implementation Consortium (CPIC).

James M Hoffman, Henry M Dunnenberger, J Kevin Hicks, Kelly E Caudle, Michelle Whirl Carrillo, Robert R Freimuth, Marc S Williams, Teri E Klein, Josh F Peterson

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Evaluation of the Integration of Genetics and Genomics Into Nursing Practice.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026
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  9. Review
  10. Article
  11. Review
  12. Review
  13. PharmaKoVariome database for supporting genetic testing.Database : the journal of biological databases and curation · 2022
    Article
  14. Advancing Pharmacogenomics from Single-Gene to Preemptive Testing.Annual review of genomics and human genetics · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. A Comprehensive Review ofPharmaceuticals (Basel, Switzerland) · 2021
    Review
  19. Approaches to assessing the provider experience with clinical pharmacogenomic information: a scoping review.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James M HoffmanDepartment of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA James.Hoffman@stjude.org.
Henry M DunnenbergerCenter for Molecular Medicine, NorthShore University HealthSystem, Evanston, IL, USA.
J Kevin HicksPharmacy Department and Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Kelly E CaudleDepartment of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Michelle Whirl CarrilloDepartment of Genetics, Stanford University, Stanford, CA, USA.
Robert R FreimuthDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Marc S WilliamsGenomic Medicine Institute, Geisinger Health System, Danville, PA, USA.
Teri E KleinDepartment of Genetics, Stanford University, Stanford, CA, USA.
Josh F PetersonDepartments of Medicine and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

PharmGKB: pharmacogenomics knowledge for precision medicineR24GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO, KLEIN, TERI ELLEN · 2010 to 2018
$25.2M
Pharmacogenetics of Phase II Drug Metabolizing EnzymesU19GM061388 · NIGMS · MAYO CLINIC ROCHESTER · PI WEINSHILBOUM, RICHARD M. · 2010 to 2014
$15.8M
Pharmacogenomics of Anti-platlet Intervention-2 (PAPI-2) StudyU01HL105198 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2010 to 2014
$13.6M
Integrated, Individualized, Intelligent Prescribing (I3P)U01HG007253 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LEVY, MIA A., PETERSON, JOSEPH F. · 2014 to 2018
$4.6M
Clinical Pharmacogenetics Implementation Consortium (CPIC)R24GM115264 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KLEIN, TERI ELLEN, RELLING, MARY V · 2015 to 2017
$3.6M
NHGRI NIH HHS U01 HG007253NHLBI NIH HHS U01 HL105198NIGMS NIH HHS R24 GM061374NIGMS NIH HHS R24 GM115264NIGMS NIH HHS U19 GM061388
6 · The paper itself

Abstract

To move beyond a select few genes/drugs, the successful adoption of pharmacogenomics into routine clinical care requires a curated and machine-readable database of pharmacogenomic knowledge suitable for use in an electronic health record (EHR) with clinical decision support (CDS). Recognizing that EHR vendors do not yet provide a standard set of CDS functions for pharmacogenetics, the Clinical Pharmacogenetics Implementation Consortium (CPIC) Informatics Working Group is developing and systematically incorporating a set of EHR-agnostic implementation resources into all CPIC guidelines. These resources illustrate how to integrate pharmacogenomic test results in clinical information systems with CDS to facilitate the use of patient genomic data at the point of care. Based on our collective experience creating existing CPIC resources and implementing pharmacogenomics at our practice sites, we outline principles to define the key features of future knowledge bases and discuss the importance of these knowledge resources for pharmacogenomics and ultimately precision medicine.

Indexed as

Databases, FactualPharmacogeneticsPrecision MedicineDecision Support Systems, ClinicalElectronic Health RecordsHumansKnowledge Basesclinical decision support systemselectronic health recordsknowledge basespharmacogeneticsprecision medicine

Identifiers

PMID27026620
PMCPMC6080683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.