ArticleEuropean journal of clinical nutrition2016
Association between folate status and cervical intraepithelial neoplasia.
Article in European journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Effects of folate supplementation on recurrence and metabolic status of cervical intraepithelial neoplasia grade 2/3 in overweight and obese women: a randomized double-blind placebo-controlled trial.European journal of clinical nutrition · 2022Trial
- Folic acid inhibits the Wnt/β-catenin pathway by upregulating DKK3 to exert anti-tumor effects in cervical squamous cell carcinoma.Scientific reports · 2025Article
- A population-based study of interactions between high-risk human papillomavirus infection and vaginal local cytokines CD4 CD8 IL-10 with cervical intraepithelial neoplasia.Frontiers in oncology · 2025Article
- The influence of nutrition on HPV-associated inflammation: a systematic review and meta-analysis.Frontiers in nutrition · 2025Article
- IL-32/NFκB/miR-205 loop sustains the high expression of IL-32 and enhances the motility of cervical cancer cells.Human cell · 2024Article
- Association between Serum Folate and Vaginal High-Risk Human Papillomavirus Infections in United States Women.The Journal of nutrition · 2024Article
- Nut consumption and urogenital and genital, gastrointestinal and women-related cancers: Assessment and review.Chronic diseases and translational medicine · 2023Review
- The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm.Healthcare (Basel, Switzerland) · 2023Review
- Association between red blood cell folate and Trichomonas vaginalis infection among women.BMC infectious diseases · 2023Article
- Interactions between vaginal local cytokine IL-2 and high-risk human papillomavirus infection with cervical intraepithelial neoplasia in a Chinese population-based study.Frontiers in cellular and infection microbiology · 2023Article
- Smart nanomaterials for cancer diagnosis and treatment.Nano convergence · 2022Review
- Intake of food groups and cervical cancer in women at risk for cervical cancer: A nested case-control study.Caspian journal of internal medicine · 2022Article
- Predict the Progression of Cervical Intraepithelial Neoplasia by a Novel Marker Folate Combine with FRα, p16 and Ki-67.International journal of general medicine · 2022Article
- Review
- Review
- Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study.Journal of Cancer · 2021Article
- Association of Diet Quality and Dietary Components with Clinical Resolution of HPV.Nutrition and cancer · 2021Observational
- Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study.Nutrition & metabolism · 2020Article
- Prevalence, genotype distribution and risk factors of cervical HPV infection in Yangqu, China: a population-based survey of 10086 women.Human vaccines & immunotherapeutics · 2020Article
- Predictive value of p16Experimental and therapeutic medicine · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesTo investigate the effect of folate status on cervical intraepithelial neoplasia (CIN) progression and its relationship with high-risk human papillomavirus (hrHPV). SUBJECTS/
methodsWe evaluated 20 000 sexually active women aged <65 years in Yangqu County by using a questionnaire; the subjects were also screened using the ThinPrep cytologic test (TCT). Patients with abnormal TCT results (other than glandular cell abnormalities) who were willing to provide informed consent were further diagnosed using colposcopy and histopathological examination. We investigated 247 cases of low-grade cervical squamous intraepithelial lesions (LSIL), 125 cases of high-grade cervical squamous intraepithelial lesions (HSIL) and 877 controls. A 24-item food frequency questionnaire was filled out by the investigator to estimate the consumption of dietary folate. Positivity for hrHPV from residual exfoliated cervical cells was tested; serum folate was also measured.
resultsThe hrHPV infection rate in HSIL patients (77.6%) was higher than that in LSIL (33.2%) and control (32.0%) patients. Dietary folate intakes in controls, LSIL and HSIL were 306.9±176.6, 321.8±168.0 and 314.7±193.8 μg/kcal, respectively. The levels of serum folate in controls, LSIL and HSIL were 18.2±7.9, 15.9±7.1 and 14.3±7.5 nmol/l, respectively. Increased CIN correlated with higher rates of hrHPV infection and lower levels of serum folate.
conclusionsLow levels of serum folate may increase the risk of CIN progression. Furthermore, potential synergy may exist between low serum folate levels and hrHPV infection to promote CIN development.
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