ReviewCurrent environmental health reports2016
Perchlorate in Water Supplies: Sources, Exposures, and Health Effects.
Review in Current environmental health reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Interference on Iodine Uptake and Human Thyroid Function by Perchlorate-Contaminated Water and Food.Nutrients · 2020Pooled it
- Associations of maternal urinary perchlorate, thiocyanate, and nitrate with maternal thyroid function during pregnancy: Modification by iodine status in the MARBLES study.Environmental research · 2026Article
- Review
- Perchlorate in stratospheric aerosol particles.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Association of urinary perchlorate, nitrate, and thiocyanate concentrations with pulmonary function in children aged 6-19 years.BMC public health · 2025Article
- Article
- Advancing in vitro assessment of iodide uptake inhibition: integrating a novel biotransformation pretreatment step.Archives of toxicology · 2025Article
- Long-Term Survivability of TardigradeLife (Basel, Switzerland) · 2024Article
- Dietary exposure assessment of perchlorate and chlorate in infant formulas marketed in Shanghai, China.Science in One Health · 2024Article
- Predictive factors for the diagnosis of permanent congenital hypothyroidism and its temporal changes in Sergipe, Brazil - A real-life retrospective study.Archives of endocrinology and metabolism · 2023Article
- The association between perchlorate in drinking water and height and weight of children and adolescents in Southwest China: a retrospective cross-sectional study.Frontiers in public health · 2023Review
- Common Chemical Pollutants Causing a Lot of Ill Health.Integrative medicine (Encinitas, Calif.) · 2022Article
- Trends in the Exposure, Distribution, and Health Risk Assessment of Perchlorate among Crayfish in the Middle and Lower Reaches of the Yangtze River.Foods (Basel, Switzerland) · 2022Article
- Occurrence, distribution and dynamics of perchlorate in soil, water, fertilizers, vegetables and fruits and associated human exposure in Chile.Environmental geochemistry and health · 2022Article
- The risk of perchlorate and iodine on the incidence of thyroid tumors and nodular goiter: a case-control study in southeastern China.Environmental health : a global access science source · 2022Article
- An Ion Chromatography Method for Simultaneous Quantification of Chromate, Arsenate, Selenate, Perchlorate, and Other Inorganic Anions in Environmental Media.Environmental engineering science · 2021Article
- The science of spin: targeted strategies to manufacture doubt with detrimental effects on environmental and public health.Environmental health : a global access science source · 2021Article
- Apoptotic endocrinal toxic effects of perchlorate in human placental cells.Toxicology reports · 2021Article
- A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges.Environmental research · 2020Review
- Food Additives and Child Health.Pediatrics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Perchlorate exposure occurs from ingestion of natural or man-made perchlorate in food or water. Perchlorate is used in a variety of industrial products including missile fuel, fireworks, and fertilizers, and industrial contamination of drinking water supplies has occurred in a number of areas. Perchlorate blocks iodide uptake into the thyroid and decreases the production of thyroid hormone, a critical hormone for metabolism, neurodevelopment, and other physiologic functions. Occupational and clinical dosing studies have not identified clear adverse effects, but may be limited by small sample sizes, short study durations, and the inclusion of mostly healthy adults. Expanding evidence suggests that young children, pregnant women, fetuses, and people co-exposed to similarly acting agents may be especially susceptible to perchlorate. Given the ubiquitous nature of perchlorate exposure, and the importance of thyroid hormone for brain development, studying the impact of perchlorate on human health could have far-reaching public health implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.