ArticleNature communications2016
A developmentally regulated switch from stem cells to dedifferentiation for limb muscle regeneration in newts.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 100 citations in OpenAlex.
- Article
- Non-canonical muscle stem cells and other lessons from regenerative vertebrates.NPJ Regenerative medicine · 2026Review
- Regeneration of Bone, Cartilage, and Tooth Following Lower Jaw Amputation in Newts.Biomedicines · 2026Article
- Putative muscle stem cells promoteProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Actin mesh in Re-epithelialization during skin regeneration in adult newt (Regenerative therapy · 2025Article
- Differentiated muscle cells of salamander Pleurodeles waltl re-enter the cell cycle.Histochemistry and cell biology · 2025Article
- Sustained induction of autophagy enhances survival during prolonged starvation in newt cells.Life science alliance · 2025Article
- One-step Cre-loxP organism creation by TAx9.Communications biology · 2025Article
- Investigating Neotenic and Metamorphic Axolotl Brain Complexity: A Stereological and Immunohistochemical Perspective.The Journal of comparative neurology · 2025Article
- RNase L represses hair follicle regeneration through altered innate immune signaling.The Journal of clinical investigation · 2025Article
- An adult myogenic cell line of the Japanese fire-bellied newt Cynops pyrrhogaster.Scientific reports · 2024Article
- Development of a ZRS Reporter System for the Newt (Biomedicines · 2024Article
- Hallmarks of regeneration.Cell stem cell · 2024Review
- Tail and Spinal Cord Regeneration in Urodelean Amphibians.Life (Basel, Switzerland) · 2024Review
- Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish.NPJ Regenerative medicine · 2024Article
- Comparison of hypoxia- and hyperoxia-induced alteration of epigene expression pattern in lungs of Pleurodeles waltl and Mus musculus.PloS one · 2024Article
- Distinct stem-like cell populations facilitate functional regeneration of the Cladonema medusa tentacle.PLoS biology · 2023Article
- Article
- Structural and functional analysis of the newt lymphatic system.Scientific reports · 2023Article
- Limb blastema formation: How much do we know at a genetic and epigenetic level?The Journal of biological chemistry · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
The newt, a urodele amphibian, is able to repeatedly regenerate its limbs throughout its lifespan, whereas other amphibians deteriorate or lose their ability to regenerate limbs after metamorphosis. It remains to be determined whether such an exceptional ability of the newt is either attributed to a strategy, which controls regeneration in larvae, or on a novel one invented by the newt after metamorphosis. Here we report that the newt switches the cellular mechanism for limb regeneration from a stem/progenitor-based mechanism (larval mode) to a dedifferentiation-based one (adult mode) as it transits beyond metamorphosis. We demonstrate that larval newts use stem/progenitor cells such as satellite cells for new muscle in a regenerated limb, whereas metamorphosed newts recruit muscle fibre cells in the stump for the same purpose. We conclude that the newt has evolved novel strategies to secure its regenerative ability of the limbs after metamorphosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.