Evidence map›Paper›PMID 27026087›Full record

Trial reportTrials2016

Effects of transcutaneous electrical nerve stimulation (TENS) on arterial stiffness and blood pressure in resistant hypertensive individuals: study protocol for a randomized controlled trial.

José Fernando Vilela-Martin, Luiz Tadeu Giollo-Junior, Gaspar Rogério Chiappa, Gerson Cipriano-Junior, Paulo José Cardoso Vieira, Fábio dos Santos Ricardi, Manoel Ildefonso Paz-Landim, Days Oliveira de Andrade, Elizabeth do Espírito Santo Cestário, Luciana Neves Cosenso-Martin and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02365974 (Effects of Transcutaneous Electrical Nerve Stimulation), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02365974 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Arterial Stiffness and Blood Pressure in Resistant Hypertensive Individuals

TypeinterventionalSponsorHospital de BaseRan2021 to 2022Enrolled64ConditionsHypertension, Vascular Stiffness, Autonomic Nervous System DiseasesArmsTranscutaneous Electrical Stimulation, No Transcutaneous Electrical Stimulation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

José Fernando Vilela-MartinInternal Medicine Department and Hospital de Base, Hypertension Clinic, Medical School in São José do Rio Preto (FAMERP), Av Anísio Haddad 7700 casa 129, Jd das Palmeiras, 15093-000, São José do Rio Preto, SP, Brazil. vilelamartin@uol.com.br.
Luiz Tadeu Giollo-JuniorInternal Medicine Department and Hospital de Base, Hypertension Clinic, Medical School in São José do Rio Preto (FAMERP), Av Anísio Haddad 7700 casa 129, Jd das Palmeiras, 15093-000, São José do Rio Preto, SP, Brazil.
Gaspar Rogério ChiappaCardiology Division, Federal University of Rio Grande do Sul (UFRS), Porto Alegre, Brazil.
Gerson Cipriano-JuniorPhysical Therapy Division, University of Brasilia (UNB), Brasilia, Brazil.
Paulo José Cardoso VieiraCardiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Fábio dos Santos RicardiInternal Medicine Department and Hospital de Base, Hypertension Clinic, Medical School in São José do Rio Preto (FAMERP), Av Anísio Haddad 7700 casa 129, Jd das Palmeiras, 15093-000, São José do Rio Preto, SP, Brazil.
Manoel Ildefonso Paz-LandimInternal Medicine Department and Hospital de Base, Hypertension Clinic, Medical School in São José do Rio Preto (FAMERP), Av Anísio Haddad 7700 casa 129, Jd das Palmeiras, 15093-000, São José do Rio Preto, SP, Brazil.
Days Oliveira de AndradeInternal Medicine Department and Hospital de Base, Hypertension Clinic, Medical School in São José do Rio Preto (FAMERP), Av Anísio Haddad 7700 casa 129, Jd das Palmeiras, 15093-000, São José do Rio Preto, SP, Brazil.
Elizabeth do Espírito Santo CestárioInternal Medicine Department and Hospital de Base, Hypertension Clinic, Medical School in São José do Rio Preto (FAMERP), Av Anísio Haddad 7700 casa 129, Jd das Palmeiras, 15093-000, São José do Rio Preto, SP, Brazil.
Luciana Neves Cosenso-MartinInternal Medicine Department and Hospital de Base, Hypertension Clinic, Medical School in São José do Rio Preto (FAMERP), Av Anísio Haddad 7700 casa 129, Jd das Palmeiras, 15093-000, São José do Rio Preto, SP, Brazil.
Juan Carlos Yugar-ToledoInternal Medicine Department and Hospital de Base, Hypertension Clinic, Medical School in São José do Rio Preto (FAMERP), Av Anísio Haddad 7700 casa 129, Jd das Palmeiras, 15093-000, São José do Rio Preto, SP, Brazil.
José Paulo CipulloInternal Medicine Department and Hospital de Base, Hypertension Clinic, Medical School in São José do Rio Preto (FAMERP), Av Anísio Haddad 7700 casa 129, Jd das Palmeiras, 15093-000, São José do Rio Preto, SP, Brazil.
Faculdade de Medicina de São José do Rio Preto · BRHospital de Base · BRHospital de Clínicas de Porto Alegre · BRUniversidade de Brasília · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResistant hypertension (RH) treatment requires an adequate and intense therapeutic approach. However, the results are not always satisfactory despite intensive treatment. Of the different pathophysiological mechanisms involved in the pathogenesis of RH, sympathetic overstimulation and therapies that block the sympathetic system have been widely studied. These approaches, however, are invasive and expensive. Another possible approach is by transcutaneous electrical nerve stimulation (TENS), a noninvasive method that modulates activity by using low-frequency transcutaneous electrical stimulation to inhibit primary afferent pathways. Thus, the current study will evaluate the effect of applying TENS in the cervicothoracic region of subjects with RH and will seek to develop a new low-cost and readily available therapy to treat this group of hypertensive individuals. METHODS/

designThis is a randomized, single blind (subject), parallel-assignment study controlled with a sham group and including participants aged 40 to 70 years with resistant hypertension. The trial has two arms: the treatment and control (sham group). The treatment group will be submitted to the stimulation procedure (TENS). The sham group will not be submitted to stimulation. The primary outcomes will be a reduction in the peripheral blood pressure and adverse events. The secondary outcomes will be a reduction the central blood pressure. The study will last 30 days. The sample size was calculated assuming an alpha error of 5 % to reject the null hypothesis with a statistical power of 80 %, thereby resulting in 28 participants per group (intervention versus sham). DISCUSSION: In recent decades, RH has become very common and costly. Adequate control requires several drugs, and in many cases, treatment is not successful. Sympathetic nervous system inhibition by renal denervation and central inhibition have significant effects in reducing BP; however, these treatments are costly and invasive. Another type of sympathetic nervous system inhibition can also be noninvasively achieved by electric current. Therefore, the application of TENS may be a new therapeutic option for treating resistant hypertensive individuals.

trial registrationClinical Trials NCT02365974.

Indexed as

Arterial PressureDrug ResistanceVascular StiffnessAdultAgedAntihypertensive AgentsBrazilClinical ProtocolsFemaleHumansHypertensionMaleMiddle AgedResearch DesignSingle-Blind MethodTime FactorsAntihypertensive AgentsArterial stiffnessBlood pressureResistant hypertensionSympathetic systemTranscutaneous electrical nerve stimulation

Identifiers

PMID27026087
PMCPMC4812656
OpenAlexW2313043599

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.