Evidence map›Paper›PMID 27025955›Full record

ArticleToxicologic pathology2016

Aerosolized Silver Nanoparticles in the Rat Lung and Pulmonary Responses over Time.

Rona M Silva, Donald S Anderson, Janice Peake, Patricia C Edwards, Esther S Patchin, Ting Guo, Terry Gordon, Lung Chi Chen, Xiaolin Sun, Laura S Van Winkle and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicologic pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. The Toxicology of Engineered Nanomaterials in Asthma.Current environmental health reports · 2018
    Review
  14. Article
  15. Article
  16. Article
  17. Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Rona M SilvaCenter for Health and the Environment, University of California, Davis, California, USA.
Donald S AndersonCenter for Health and the Environment, University of California, Davis, California, USA.
Janice PeakeCenter for Health and the Environment, University of California, Davis, California, USA.
Patricia C EdwardsCenter for Health and the Environment, University of California, Davis, California, USA.
Esther S PatchinCenter for Health and the Environment, University of California, Davis, California, USA.
Ting GuoDepartment of Chemistry, University of California, Davis, California, USA.
Terry GordonDepartment of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York, USA.
Lung Chi ChenDepartment of Environmental Medicine, Langone Medical Center, New York University, Tuxedo, New York, USA.
Xiaolin SunCenter for Health and the Environment, University of California, Davis, California, USA Shandong University, School of Control Science and Engineering, Jinan, Shandong Province, China.
Laura S Van WinkleCenter for Health and the Environment, University of California, Davis, California, USA.
Kent E PinkertonCenter for Health and the Environment, University of California, Davis, California, USA kepinkerton@ucdavis.edu.
University of California, Davis · USNYU Langone Health · USShandong University · CN

Funding

Acute and Chronic In vivo Effects of Engineered NanomaterialsU01ES020126 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON, TERRY · 2010 to 2014
$2.5M
Engineered Nanomaterials: Linking Physical and Chemical Properties to BiologyU01ES020127 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PINKERTON, KENT ED · 2010 to 2014
$2.5M
NIEHS NIH HHS U01 ES020126NIEHS NIH HHS U01 ES020127
6 · The paper itself

Abstract

Silver nanoparticle (Ag NP) production methods are being developed and refined to produce more uniform Ag NPs through chemical reactions involving silver salt solutions, solvents, and capping agents to control particle formation. These chemical reactants are often present as contaminants and/or coatings on the Ag NPs, which could alter their interactions in vivo. To determine pulmonary effects of citrate-coated Ag NPs, Sprague-Dawley rats were exposed once nose-only to aerosolized Ag NPs (20 nm [C20] or 110 nm [C110] Ag NPs) for 6 hr. Bronchoalveolar lavage fluid (BALF) and lung tissues were obtained at 1, 7, 21, and 56 days postexposure for analyses. Inhalation of Ag NPs, versus citrate buffer control, produced significant inflammatory and cytotoxic responses that were measured in BALF cells and supernatant. At day 7, total cells, protein, and lactate dehydrogenase were significantly elevated in BALF, and peak histopathology was noted after C20 or C110 exposure versus control. At day 21, BALF polymorphonuclear cells and tissue inflammation were significantly greater after C20 versus C110 exposure. By day 56, inflammation was resolved in Ag NP-exposed animals. Overall, results suggest delayed, short-lived inflammatory and cytotoxic effects following C20 or C110 inhalation and potential for greater responses following C20 exposure.

Indexed as

Administration, InhalationAnimalsBronchoalveolar Lavage FluidLungMaleMetal NanoparticlesParticle SizeRatsRats, Sprague-DawleySilverSilverengineered nanomaterialinflammationinhalation exposurepulmonary toxicity

Identifiers

PMID27025955
PMCPMC4912458
OpenAlexW2323689614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.