ArticleJournal of the American Heart Association2016
Diastolic Left Ventricular Function in Relation to Circulating Metabolic Biomarkers in a General Population.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Metabolomic Markers of Left Ventricular Structure, Diastolic Function, and Risk of Coronary Heart Disease: A Longitudinal Study in American Indian Individuals.Journal of the American Heart Association · 2026Article
- Ventricular-arterial coupling is preserved in prematurely born 11-year-old children but calls for life-long prevention of hemodynamic deterioration.Journal of hypertension · 2026Article
- Integrated analysis of blood microbiome and metabolites reveals key biomarkers and functional pathways in myocardial infarction.Journal of translational medicine · 2025Article
- Gut microbiota, blood metabolites, and left ventricular diastolic dysfunction in US Hispanics/Latinos.Microbiome · 2024Article
- Cardiovascular risk of metabolically healthy obesity in two european populations: Prevention potential from a metabolomic study.Cardiovascular diabetology · 2023Article
- Metabolomics and cardiovascular imaging: a combined approach for cardiovascular ageing.ESC heart failure · 2021Review
- Metabolomic Profiling of Left Ventricular Diastolic Dysfunction in Women With or at Risk for HIV Infection: The Women's Interagency HIV Study.Journal of the American Heart Association · 2020Article
- Novel Findings From a Metabolomics Study of Left Ventricular Diastolic Function: The Bogalusa Heart Study.Journal of the American Heart Association · 2020Article
- Female Heart Health: Is GPER the Missing Link?Frontiers in endocrinology · 2019Review
- The Future of "Omics" in Hypertension.The Canadian journal of cardiology · 2017Review
- Electro-echocardiographic Indices to Predict Cardiac Resynchronization Therapy Non-response on Non-ischemic Cardiomyopathy.Scientific reports · 2017Article
- Left Ventricular Structure and Function in Relation to Environmental Exposure to Lead and Cadmium.Journal of the American Heart Association · 2017Article
- Diastolic Left Ventricular Function in Relation to Circulating Metabolic Biomarkers in a General Population.Journal of the American Heart Association · 2016Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundThe metabolic signature associated with subclinical diastolic left ventricular (LV) dysfunction in the population remains ill defined. METHODS AND
resultsIn 711 randomly recruited Flemish (50.8% women; mean age, 50.8 years), we assessed echocardiographic Doppler indexes of diastolic LV function in relation to 44 circulating metabolites determined by nuclear magnetic resonance spectroscopy. In multivariable-adjusted regression analysis with Bonferroni correction of significance levels applied, peak a' decreased (P≤0.048) and e'/a' increased (P≤0.044) with circulating tyrosine, high-density lipoprotein apolipoproteins, glucose+glutamine, and an unidentified molecule. Effect sizes expressed per 1-SD increment in the metabolite ranged from -0.277 to -0.203 cm/s for peak a' and from +0.047 to +0.054 for e'/a'. In addition, peak a' decreased (P≤0.031) with glucose+2-aminobutyrate (-0.261 cm/s) and glucose+2-phosphoglycerate (-0.209 cm/s). In partial least square discriminant analysis (PLS-DA), metabolites associated with normal diastolic LV function (n=538) included glucose+glutamine, glucose+2-aminobutyrate, and glucose+2-phosphoglycerate, whereas those siding with abnormal function encompassed 4-aminobutyrate, 4-hydroxybutyrate, creatinine, and phosphocholine. In receiver operating characteristics plots, adding 3 latent factors identified by PLS-DA to prohormone brain natriuretic peptide increased (P<0.0001) the area under the curve from 0.64 (95% CI, 0.58-0.68) to 0.73 (0.68-0.78).
conclusionsIn a general population, circulating metabolites indicative of energy substrate utilization and protection against oxidative stress differentiated normal from abnormal diastolic LV function. These findings improve our understanding of the pathophysiology underlying deterioration of diastolic LV function and potentially point to new targets for prevention and treatment of this condition.
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