ArticleLasers in medical science2016
Morphology, proliferation, and gene expression of gingival fibroblasts on Laser-Lok, titanium, and zirconia surfaces.
Article in Lasers in medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- 3D-printed Cu-bearing titanium alloy crowns for pediatric oral health: biocompatibility, antibacterial activity, and internal fit.Journal of advanced research · 2026Article
- Sintering Method-Dependent Hydroxyapatite Coatings Drive Enhanced Gingival Fibroblast Behavior on Titanium Implant Surfaces.Materials (Basel, Switzerland) · 2026Article
- Influence of Machining, Polishing, and Glazing on Surface Properties and Biological Performance of Zirconia and Lithium Disilicate Dental Ceramics.Journal of functional biomaterials · 2025Article
- Effects of Different Surface Treatments and Accelerated Aging on Dental Zirconia-An In Vitro Study.Journal of functional biomaterials · 2025Article
- Review
- Review
- Enhancement of Biocompatibility of High-Transparency Zirconia Abutments with Human Gingival Fibroblasts via Cold Atmospheric Plasma Treatment: An In Vitro Study.Journal of functional biomaterials · 2024Article
- The integration of peri-implant soft tissues around zirconia abutments: Challenges and strategies.Bioactive materials · 2023Review
- Laser microgrooving and resorbable blast texturing for enhanced surface function of titanium alloy for dental implant applications.Biomedical engineering advances · 2023Article
- Photobiomodulation using LLLT and LED of cells involved in osseointegration and peri-implant soft tissue healing.Lasers in medical science · 2022Article
- The effects of using erbium, chromium-doped:yttrium-scandium-gallium-garnet laser on the surface modification, bacterial decontamination, and cell adhesion on zirconia discs: an in vitro study.Lasers in medical science · 2021Article
- Biological efficacy of perpendicular type-I collagen protruded from TiOInternational journal of oral science · 2020Article
- Influence of Implant Material and Surface on Mode and Strength of Cell/Matrix Attachment of Human Adipose Derived Stromal Cell.International journal of molecular sciences · 2020Article
- The Osteogenetic Potential of Chitosan Coated Implant: AnJournal of stem cells & regenerative medicine · 2020Article
- Viability and collagen secretion by fibroblasts on titanium surfaces with different acid-etching protocols.International journal of implant dentistry · 2019Article
- Improvements on biological and antimicrobial properties of titanium modified by AgNPs-loaded chitosan-heparin polyelectrolyte multilayers.Journal of materials science. Materials in medicine · 2019Article
- Impact of Nano-Crystalline Diamond Enhanced Hydrophilicity on Cell Proliferation on Machined and SLA Titanium Surfaces: An In-Vivo Study in Rodents.Nanomaterials (Basel, Switzerland) · 2018Article
- Histological differences in the adherence of connective tissue to laser-treated abutments and standard abutments for dental implants. An experimental pilot study in humans.Medicina oral, patologia oral y cirugia bucal · 2017Article
- Biocompatibility of Titania Nanotube Coatings Enriched with Silver Nanograins by Chemical Vapor Deposition.Nanomaterials (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soft tissue seal plays a critical role in long-term success of dental implants, and the effects of implant surface treatments such as laser ablation have been a topic of particular interest in this respect. Considering the existing controversy regarding soft tissue behavior in contact with implant surfaces, this study sought to assess the morphology, proliferation, and gene expression of human gingival fibroblasts (HGFs) on different abutment surfaces. In this in vitro, experimental study, HGFs were cultured on 45 discs (Laser-Lok, titanium, and zirconia). Cell morphology, proliferation rate, and interleukin 10 (IL-10), tumor necrosis factor alpha (TNFα), fibronectin, and integrin gene expressions were assessed by electron microscopy, methyl thiazol tetrazolium (MTT) assay, and real-time polymerase chain reaction (PCR), respectively. Data were analyzed using ANOVA and the Kruskal-Wallis H test. Fibroblast attachment was noted in all the three groups. Spindle-shaped cells with pseudopod-like processes were more frequently seen in the Laser-Lok group. Cell proliferation was significantly higher in the Laser-Lok group compared to those in the other groups (P = 0.0002). Significant differences were found in the expression of IL-10, TNFα, fibronectin, and integrin genes among the groups (P < 0.01). Within the limitations of this study, HGFs on Laser-Lok surfaces had a more mature morphology and greater proliferation and differentiation as compared to those on zirconia and titanium surfaces. This indicates better attachment of these cells to laser-modified surfaces, creating a more efficient soft tissue seal around dental implants.
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Registered trials
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