Evidence map›Paper›PMID 27025826›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016

Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections.

Alan R Hauser, Joan Mecsas, Donald T Moir

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 144 citations in OpenAlex.

  1. Article
  2. Review
  3. Harnessing phages to tackle antimicrobial resistance: a Saudi Arabian perspective.Frontiers in cellular and infection microbiology · 2025
    Review
  4. Article
  5. Beyond Antibiotics: What the Future Holds.Antibiotics (Basel, Switzerland) · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Flourishing Antibacterial Strategies for Osteomyelitis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  11. Article
  12. Frontiers in microbiology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Six Bacterial Vaginosis-Associated Species Can Form anFrontiers in cellular and infection microbiology · 2022
    Article
  19. Investigating the Antimicrobial Activity of Vancomycin-Loaded Soy Protein Nanoparticles.Interdisciplinary perspectives on infectious diseases · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Alan R HauserDepartments of Microbiology/Immunology and Medicine, Northwestern University, Chicago, Illinois.
Joan MecsasTufts University School of Medicine, Boston.
Donald T MoirMicrobiotix, Inc, Worcester, Massachusetts.
Microbiotix (United States) · USNorthwestern University · USTufts University · US

Funding

Population Analysis of Pseudomonas aeruginosa VirulenceR01AI118257 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HAUSER, ALAN R · 2016 to 2025
$4.9M
Mechanistic Studies of Patatin-like ToxinsR01AI053674 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HAUSER, ALAN R · 2003 to 2017
$4.3M
Validating targets in p. aeruginosa type III secretion using chemical probesR01AI099269 · NIAID · MICROBIOTIX, INC · PI MOIR, DONALD T · 2012 to 2015
$3.2M
Initiation and regulation of antibacterial innate immunityR01AI113166 · NIAID · TUFTS UNIVERSITY BOSTON · PI MECSAS, JOAN C · 2014 to 2018
$2.4M
Patient-Oriented Research on Pseudomonas aeruginosaK24AI104831 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HAUSER, ALAN R · 2013 to 2024
$1.2M
NIAID NIH HHS K24 AI104831NIAID NIH HHS R01 AI053674NIAID NIH HHS R01 AI099269NIAID NIH HHS R01 AI113166NIAID NIH HHS R01 AI118257
6 · The paper itself

Abstract

The utility of conventional antibiotics for the treatment of bacterial infections has become increasingly strained due to increased rates of resistance coupled with reduced rates of development of new agents. As a result, multidrug-resistant, extensively drug-resistant, and pandrug-resistant bacterial strains are now frequently encountered. This has led to fears of a "postantibiotic era" in which many bacterial infections will be untreatable. Alternative nonantibiotic treatment strategies need to be explored to ensure that a robust pipeline of effective therapies is available to clinicians. In this review, we highlight some of the recent developments in this area, such as the targeting of bacterial virulence factors, utilization of bacteriophages to kill bacteria, and manipulation of the microbiome to combat infections.

Indexed as

Bacterial InfectionsMicrobiotaAnimalsAnti-Bacterial AgentsBacterial Secretion SystemsBacteriophagesBiomedical ResearchHumansMicePhage TherapyVirulence FactorsAnti-Bacterial AgentsBacterial Secretion SystemsVirulence Factorsantivirulence therapybacteriamicrobiomephage therapysecretion systems

Identifiers

PMID27025826
PMCPMC4901866
OpenAlexW2316784264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.