ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2016
Factors in the Selection of Surface Disinfectants for Use in a Laboratory Animal Setting.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Temperature-dependent infectious stability of Severe fever with thrombocytopenia syndrome virus.The Journal of veterinary medical science · 2026Article
- Evaluation of the Efficacy of Disinfectants in Reducing Contamination of Bacterial and Viral Murine Pathogens on Gloved Hands.Journal of the American Association for Laboratory Animal Science : JAALAS · 2024Article
- Article
- Study ofAnimals : an open access journal from MDPI · 2024Article
- Environmental detection and spreading of mpox in healthcare settings: a narrative review.Frontiers in microbiology · 2023Review
- Effect of Husbandry Practices on the Fecal Microbiota of C57BL/6J Breeding Colonies Housed in 2 Different Barrier Facilities in the Same Institution.Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Comparison of Floor Cleaning and Disinfection Processes in a Research Animal Facility.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Inactivation of SARS-CoV-2 by a chitosan/α-AgScientific reports · 2022Article
- Evaluation of Effects of Laboratory Disinfectants on Mouse Gut Microbiota.Comparative medicine · 2021Article
- Considerations for the Selection and Use of Disinfectants Against SARS-CoV-2 in a Health Care Setting.Open forum infectious diseases · 2020Article
- Surviving Reactive Chlorine Stress: Responses of Gram-Negative Bacteria to Hypochlorous Acid.Microorganisms · 2020Review
- Safety Evaluation of Individual Pillboxes to Control Cross-Contamination in the Drug Circuit in Hospitals.International journal of environmental research and public health · 2019Article
- Evaluation of Peroxides and Chlorine Oxides as Disinfectants for Chemical Sterilization of Gnotobiotic Rodent Isolators.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Assessing Spatial Working Memory Using the Spontaneous Alternation Y-maze Test in Aged Male Mice.Bio-protocol · 2019Article
- Viral Vector Biosafety in Laboratory Animal Research.Comparative medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Because surface disinfectants are an important means of pathogen control within laboratory animal facilities, these products must have an appropriate spectrum of antimicrobial activity. However, many other factors must also be considered, including effects on human health, environmental safety, and animal behavior. Aqueous solutions of sodium hypochlorite often are considered to be the 'gold standard' for surface disinfection, but these products can be corrosive, caustic, and aversive in odor. This study was designed to identify disinfectants that are as effective as hypochlorite solutions but more acceptable for use in a laboratory animal setting. An antiviral disinfectant-efficacy assay was developed by using viral vectors that expressed green fluorescence protein as surrogates for wild-type viruses of concern in laboratory animals. Efficacy testing revealed that most of the products were highly effective when used against viral vectors in suspension. However, when the disinfectants were challenged by buffering virus in protein or drying virus on nonporous surfaces, the hypochlorite and peroxymonosulfate products performed the best. Review of safety data sheets for the agents indicated that a peroxide-based product was considerably safer than the other products tested and that the pH of most products was not conducive to disposal down a drain. Behavioral testing of Swiss Webster, C57Bl/6, and BALB/c mice showed that the hypochlorite- and peroxide-based products were clearly aversive, given that the mice consistently avoided these products. All of these factors must be considered when choosing the appropriate disinfectant.
Indexed as
Identifiers
27025810PMC4783637W2470695641What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.