Evidence map›Paper›PMID 27025753›Full record

ReviewAntibiotics (Basel, Switzerland)2014

Acquired Class D β-Lactamases.

Nuno T Antunes, Jed F Fisher

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Tackling the Antibiotic Resistance Caused by Class AInternational journal of molecular sciences · 2018
    Pooled it
  2. Reverse vaccinology for development of vaccine against Aeromonas hydrophila infection in nile tilapia (Oreochromis niloticus).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  3. Article
  4. Genome sequence and annotation ofMicrobiology resource announcements · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Antimicrobial Susceptibility of Toxin-ProducingAntibiotics (Basel, Switzerland) · 2025
    Article
  9. Review
  10. Article
  11. Outsmarting Nightmare: Drug Resistance inThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Review
  12. Article
  13. Article
  14. Study of Antimicrobial Resistance (AMR) inRecent advances in anti-infective drug discovery · 2024
    Review
  15. Resistance inAntibiotics (Basel, Switzerland) · 2023
    Review
  16. Review
  17. The Prevalence of Multidrug-ResistantDiagnostics (Basel, Switzerland) · 2023
    Article
  18. Review
  19. Review
  20. Whole-Genome Sequencing Reveals Diversity of Carbapenem-ResistantAntimicrobial agents and chemotherapy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nuno T AntunesDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. ngiaoant@nd.edu.
Jed F FisherDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. Jed.F.Fisher.57@nd.edu.
University of Notre Dame · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Class D β-lactamases have emerged as a prominent resistance mechanism against β-lactam antibiotics that previously had efficacy against infections caused by pathogenic bacteria, especially by Acinetobacter baumannii and the Enterobacteriaceae. The phenotypic and structural characteristics of these enzymes correlate to activities that are classified either as a narrow spectrum, an extended spectrum, or a carbapenemase spectrum. We focus on Class D β-lactamases that are carried on plasmids and, thus, present particular clinical concern. Following a historical perspective, the susceptibility and kinetics patterns of the important plasmid-encoded Class D β-lactamases and the mechanisms for mobilization of the chromosomal Class D β-lactamases are discussed.

Indexed as

carbapenemaseclass Dcrystal structurekineticsOXAplasmidβ-lactamase

Identifiers

PMID27025753
PMCPMC4790369
OpenAlexW2083533991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.