Evidence map›Paper›PMID 27025724›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2016

Tonsillar microbiota in children with PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) syndrome.

M V Tejesvi, M Uhari, T Tapiainen, A M Pirttilä, M Suokas, U Lantto, P Koivunen, M Renko

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Acute sore throat andBMJ open · 2021
    Pooled it
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  15. Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review.World journal of otorhinolaryngology - head and neck surgery · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M V TejesviGenetics and Physiology, Faculty of Science, University of Oulu, P.O. Box 3000, 90014, Oulu, Finland.
M UhariPEDEGO Research Unit, Medical Research Center Oulu, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.
T TapiainenPEDEGO Research Unit, Medical Research Center Oulu, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.
A M PirttiläGenetics and Physiology, Faculty of Science, University of Oulu, P.O. Box 3000, 90014, Oulu, Finland.
M SuokasGenetics and Physiology, Faculty of Science, University of Oulu, P.O. Box 3000, 90014, Oulu, Finland.
U LanttoPEDEGO Research Unit, Medical Research Center Oulu, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.
P KoivunenPEDEGO Research Unit, Medical Research Center Oulu, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.
M RenkoPEDEGO Research Unit, Medical Research Center Oulu, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland. marjo.renko@oulu.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a childhood febrile syndrome of unknown origin that is often cured with tonsillectomy. We aimed to compare the bacterial microbiota of the tonsils removed from PFAPA patients with those of controls. We used next-generation sequencing technology to investigate the bacterial microbiota of the tonsils of 30 PFAPA patients and 24 controls. We found significant differences in the presence and relative abundance of many bacteria between PFAPA cases and controls. For example, cyanobacteria, potential producers of microcystins and other toxins, were more common in the case samples (14/30, 47 %) than in the controls (4/24, 17 %, p = 0.02), and the mean relative abundance of cyanobacteria was higher in the case samples (0.2 %) than in the controls (0.01 %, p = 0.01). Streptococci were present in all samples in both groups, but their mean relative abundance was lower in the case samples (3.7 %) than in the controls (9.6 %, p = 0.01). Typical nasopharyngeal microbes such as fusobacteria, Prevotella, Tannerella, Porphyromonas, and Parvimonas dominated the microbiota of the tonsils in both groups. The microbiota of the tonsils removed from PFAPA patients differed significantly from those of the controls. Tonsillar microbiota may play a role in triggering the inflammatory processes that lead to symptoms of PFAPA.

Indexed as

MicrobiotaBiodiversityCase-Control StudiesChildChild, PreschoolComputational BiologyFemaleFeverHumansInfantInfant, NewbornLymphadenitisMaleMetagenomeMetagenomicsPalatine Tonsil

Identifiers

PMID27025724

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.