ArticleJournal of atherosclerosis and thrombosis2016
Heavy Alcohol Consumption is Associated with Impaired Endothelial Function.
Article in Journal of atherosclerosis and thrombosis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- The Effect of Alcohol on Blood Pressure and Hypertension.Current hypertension reports · 2021Pooled it
- The effects of alcohol consumption on flow-mediated dilation in humans: A systematic review.Physiological reports · 2021Pooled it
- Refining the assessment of cardiac dysfunction in MAFLD and MASLD: a commentary on study limitations.Hepatology international · 2026Article
- Silent brain infarcts after major cardiac interventions: a retrospective paired cohort study using high-resolution DW-MRI.BMC cardiovascular disorders · 2026Article
- Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder.Nature communications · 2026Article
- Labour-type physical activity, alcohol use and hypertension in rural older adults in Northeast China.Frontiers in public health · 2026Article
- Alcohol Consumption and Acute Coronary Syndrome: Epidemiology, Pathophysiology, and Clinical Perspectives.Journal of clinical medicine · 2025Review
- Metabolic dysfunction-associated steatotic liver disease, metabolic alcohol-related liver disease, and incident dementia: a nationwide cohort study : MASLD, MetALD, and dementia risk.BMC gastroenterology · 2025Article
- Alcohol and cause-specific mortality in Russia: the Know Your Heart Study 2015-23.BMC public health · 2024Article
- Alcohol consumption may be a risk factor for cerebrovascular stenosis in acute ischemic stroke and transient ischemic attack.BMC neurology · 2024Article
- Metabolic dysfunction-associated steatotic liver disease increases the risk of incident cardiovascular disease: a nationwide cohort study.EClinicalMedicine · 2023Article
- Article
- Alcohol and vascular endothelial function: Biphasic effect highlights the importance of dose.Alcohol, clinical & experimental research · 2023Article
- Alcohol and the vasculature: a love-hate relationship?Pflugers Archiv : European journal of physiology · 2023Review
- Association of Physical, Psychological and Psychosocial Attributes With Arterial Stiffness in Cardiovascular Disorders: A Systematic Literature Review.Journal of lifestyle medicine · 2023Review
- Blood Vessels as a Key Mediator for Ethanol Toxicity: Implication for Neuronal Damage.Life (Basel, Switzerland) · 2022Review
- Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation.Frontiers in cardiovascular medicine · 2022Review
- Vegetable nitrate intake, blood pressure and incident cardiovascular disease: Danish Diet, Cancer, and Health Study.European journal of epidemiology · 2021Article
- The Potential Role of Creatine in Vascular Health.Nutrients · 2021Review
- Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases.Current neurovascular research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimPrevious studies have reported that moderate alcohol consumption is protective against cardiovascular disease, but heavy alcohol consumption increases its risk. Endothelial dysfunction is hypothesized to contribute to the development of atherosclerosis and cardiovascular disease. However, few population-based studies have examined a potential effect of alcohol consumption on endothelial function.
methodsThis study included 404 men aged 30-79 years who were recruited from residents in 2 communities under the Circulatory Risk in Communities Study in 2013 and 2014. We asked the individuals about the frequency and volume of alcohol beverages and converted the data into grams of ethanol per day. Endothelial function was assessed by brachial artery flow-mediated dilation (FMD) measurements during reactive hyperemia. We performed cross-sectional analysis of alcohol consumption and %FMD by logistic regression analysis, adjusting for age, baseline brachial artery diameter, body mass index, systolic blood pressure, low-density lipoprotein cholesterol, HbA1c, smoking, antihypertensive medication use, and community.
resultsIndividuals who drank ≥ 46 g/day ethanol had a lower age-adjusted mean %FMD than non-drinkers (p＜0.01). Compared with non-drinkers, the age-adjusted odds ratios (ORs) (95% confidence interval) of low %FMD (＜5.3%) for former, light (＜23.0 g/day ethanol), moderate (23.0-45.9 g/day ethanol), and heavy (≥ 46.0 g/day ethanol) drinkers were 1.61 (0.67-3.89), 0.84 (0.43-1.66), 1.09 (0.52-2.25), and 2.99 (1.56-5.70), respectively. The corresponding multivariable-adjusted ORs were 1.76 (0.69-4.50), 0.86 (0.42-1.76), 0.98 (0.45-2.12), and 2.39 (1.15-4.95), respectively.
conclusionsHeavy alcohol consumption may be an independent risk factor of endothelial dysfunction in Japanese men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.