Evidence map›Paper›PMID 27025595›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016

Race-based disparities in loss of functional independence after hysterectomy for uterine cancer.

Lorraine T Dean, Xiaochen Zhang, Nawar Latif, Robert Giuntoli, Lilie Lin, Ashley Haggerty, Sarah Kim, David Shalowitz, Caitlin Stashwick, Fiona Simpkins and 4 more

Abstract read
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lorraine T DeanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ldean9@jhu.edu.
Xiaochen ZhangDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Nawar LatifDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Robert GiuntoliDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Lilie LinDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Ashley HaggertyDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Sarah KimDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
David ShalowitzDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Caitlin StashwickDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Fiona SimpkinsDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Robert BurgerDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Mark MorganDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Emily KoDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Kathryn SchmitzCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
University of Pennsylvania · USJohns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
REPRODUCTIVE EPIDEMIOLOGY TRAINING GRANTT32HD007440 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BARNHART, KURT T · 1996 to 2020
$7.5M
Social Determinants of Breast Cancer SurvivorshipK01CA184288 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DEAN, LORRAINE TIERA · 2014 to 2018
$767k
NCI NIH HHS K01 CA184288NCI NIH HHS P30 CA006973NICHD NIH HHS T32 HD007440
6 · The paper itself

Abstract

purposeRacial disparities in uterine cancer-related outcomes have been reported. The goal of this study was to determine if race, pre-operative body mass index (BMI), and medical comorbidities are predictors of loss of functional independence after hysterectomy for uterine cancer.

methodsLoss of independence was defined as a change from pre-operative functional independence, to a post-operative requirement of discharge to a post-care facility, or death within the first 30 days following uterine cancer surgery. Demographic factors, comorbidities, BMI, intra-operative and post-operative outcomes, and discharge status were abstracted from the 2011 and 2012 American College of Surgeons National Surgical Quality Improvement Program (NSQIP). Statistical analyses included multivariable logistic regression and Wald tests for interaction.

resultsA total of 4005 patients had uterine cancer and were functionally independent pre-operatively. After adjusting for clinical features and comorbidities, Black women were not significantly more likely to lose functional independence than non-Black women. However, a significant interaction (OR = 1.17, p < 0.001) was found between race and BMI for loss of functional independence. Interaction plots revealed worsening functional outcomes for Black women with BMI >40 but not in non-Blacks.

conclusionsThe interaction suggests a 17 % increased odds of losing independence for each unit of BMI difference for Black uterine cancer patients, or 170 % increased odds of losing independence for a 10-point increase in BMI, given a linear association. To reduce the likelihood of losing post-operative functional independence, Black, high-BMI patients with or at risk for uterine cancer may especially benefit from weight loss or interventions to optimize physical function.

Indexed as

FemaleHealthcare DisparitiesHumansHysterectomyMiddle AgedRacial GroupsSurvival RateUterine NeoplasmsFunctional dependenceRacial/ethnic disparitiesSurvivorshipUterine cancer

Identifiers

PMID27025595
PMCPMC4920714
OpenAlexW2329411611

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.