ArticleInfectious diseases of poverty2016
A case of human infection with a novel Babesia species in China.
Article in Infectious diseases of poverty, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Human Babesiosis in China: a systematic review.Parasitology research · 2019Pooled it
- Proteomic Identification and Functional Analysis ofJournal of tropical medicine · 2025Article
- Development of Multiplex Assays for the Identification of ZoonoticPathogens (Basel, Switzerland) · 2024Article
- Establishment of the auxin inducible degron system for Babesia duncani: a conditional knockdown tool to study precise protein regulation in Babesia spp.Parasites & vectors · 2024Article
- Human Babesia odocoilei and Bartonella spp. co-infections in the Americas.Parasites & vectors · 2024Article
- Ticks and Tick-Borne Pathogens Circulating in Peri-Domestic Areas in Mainland Portugal.Microorganisms · 2024Article
- Great genetic diversity of vector-borne bacteria and protozoan in wild rodents from Guangxi, China.PLoS neglected tropical diseases · 2024Article
- Successful treatment with doxycycline monotherapy for human infection with Babesia venatorum (Babesiidae, Sporozoa) in China: a case report and proposal for a clinical regimen.Infectious diseases of poverty · 2023Article
- Nucleic Acid Prevalence of ZoonoticTropical medicine and infectious disease · 2023Review
- Nested qPCR assay to detect Babesia duncani infection in hamsters and humans.Parasitology research · 2022Article
- Article
- The Piroplasmida Babesia, Cytauxzoon, and Theileria in farm and companion animals: species compilation, molecular phylogeny, and evolutionary insights.Parasitology research · 2022Review
- A Review of Zoonotic Babesiosis as an Emerging Public Health Threat in Asia.Pathogens (Basel, Switzerland) · 2021Review
- The Global Emergence of Human Babesiosis.Pathogens (Basel, Switzerland) · 2021Review
- Establishment of a transient transfection system for Babesia sp. Xinjiang using homologous promoters.Parasitology research · 2021Article
- Treatment of Human Babesiosis: Then and Now.Pathogens (Basel, Switzerland) · 2021Review
- The Impact of Tick-Borne Diseases on the Bone.Microorganisms · 2021Review
- Molecular Diversity of Hard Tick Species from Selected Areas of a Wildlife-Livestock Interface Ecosystem at Mikumi National Park, Morogoro Region, Tanzania.Veterinary sciences · 2021Article
- Emerging Human Babesiosis with "Ground Zero" in North America.Microorganisms · 2021Review
- Spreading of Human Babesiosis in China: Current Epidemiological Status and Future Challenges.China CDC weekly · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBabesiosis is an uncommon but emerging tick-borne disease caused by the genus Babesia. In this case study, we report a case of human infection with a novel Babesia sp. in China.
findingsThe patient in question had been suffering from repetitive occurrences of mild fever of unknown origin and fatigue for 10 years. Ring forms, tetrads, and one or two dots of chromatin or trophozoite-like organisms were observed in the patient's thin blood smears and bone marrow smears. Using a confocal laser-scanning microscope, it was observed that the patient's serum had reactivity with the surface proteins of the B. microti strain. Electron microscopy revealed oval red blood cells with 1 ~ 2 μm of knob protrusions in the cellular membrane. The results of the Babesia-specific nested PCR assay for 18S rRNA confirmed the presence of Babesia infection. The construction of a phylogenetic relationship showed clustering with B. microti and B. duncani, which was identified as a novel Babesia species and named as Babesia sp. XXB/HangZhou. Azithromycin, doxycycline, and moxifloxacin hydrochloride were shown to relieve symptoms but were not as effective after continuous usage. After atovaquone (Mepron®) administration, the patient recovered from fever and tested negative for detection of Babesia-specific genes.
conclusionBabesia sp. XXB/HangZhou is a novel Babesia species, which causes mild babesiosis in an immunocompetent patient.
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