ArticleInternational journal of oral science2016
The effect of basic fibroblast growth factor on regeneration in a surgical wound model of rat submandibular glands.
Article in International journal of oral science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The Effect of Growth Factors on Vaginal Wound Healing: A Systematic Review and Meta-analysis.Tissue engineering. Part B, Reviews · 2023Pooled it
- Regenerative capacity of human dental pulp stem cells versus their exosomes on surgically induced submandibular gland defects in rats.BMC oral health · 2026Article
- Melatonin free form versus its chitosan-loaded nano formula impact on wound healing of albino rat's parotid gland "a histological study".BMC oral health · 2025Article
- Article
- Multifunctional polysaccharide composited microneedle for oral ulcers healing.Materials today. Bio · 2023Article
- Cell-Free Therapies: The Use of Cell Extracts to Mitigate Irradiation-Injured Salivary Glands.Biology · 2023Review
- Dried human cultured epidermis accelerates wound healing in diabetic mouse skin defect wounds.Scientific reports · 2022Article
- The effect of fibroblast growth factor 7 on human dental pulp stem cells for differentiation to AQP5-positive and αSMA-positive cells in vitro and in vivo.Clinical and experimental dental research · 2021Article
- Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies.Stem cell research & therapy · 2019Review
- Using cell sheets to regenerate mouse submandibular glands.NPJ Regenerative medicine · 2019Article
- FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids.Journal of cell science · 2018Article
- Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF).International journal of nanomedicine · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study developed an animal model of surgically wounded submandibular glands (SMGs) and investigated the effects of collagen gel with basic fibroblast growth factor (bFGF) on tissue regeneration of surgically wounded SMGs in vivo. The animal model was produced by creating a surgical wound using a 3-mm diameter biopsy punch in SMGs. The wound was filled with collagen gel with bFGF (bFGF group) or without bFGF (control group). In the animal model of surgically wounded SMGs, salivary glands without scar tissue around the wound area were observed with smaller areas of collagen gel. Small round and spindle-shape cells invaded the collagen gel in both groups after operation day (AOD) 5, and this invasion dramatically increased at AOD 7. Host tissue completely replaced the collagen gel at AOD 21. The invading immune cells in the group treated with collagen gel with bFGF were positive for vimentin, α-smooth muscle actin (αSMA), CD49f, c-kit and AQP5 at AOD 7. Similarly, the mRNA expression of vimentin, αSMA, CD49f, keratin19 and AQP5 was also increased. This study suggests that the use of collagen gels with bFGF improves salivary gland regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.