ArticlePloS one2016
Genome-Wide Association Study Singles Out SCD and LEPR as the Two Main Loci Influencing Intramuscular Fat Content and Fatty Acid Composition in Duroc Pigs.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59 citing papers in PubMed, 111 citations in OpenAlex.
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- Gene expression profiling by RNA-sequencing reveals regulators of intramuscular fat in Black Slavonian pigs.Scientific reports · 2026Article
- Genes and Gene Functions Associated with Morphological, Productive, Reproductive, and Carcass Quality Traits in Pigs: A Functional Bioinformatics Approach.Current issues in molecular biology · 2026Article
- Evaluation of genetic effects on the fatty acid composition of intramuscular fat and backfat of the endangered Angler Saddleback pig.Archives animal breeding · 2026Article
- Leptin receptor gene influences pig gut microbiota both through feed intake and independently.Animal microbiome · 2025Article
- Comparative Analyses of Gene and Protein Expressions and the Lipid Contents in Intramuscular and Subcutaneous Fat Tissues in Fattening Steers.Animals : an open access journal from MDPI · 2025Article
- Single Nucleotide Polymorphisms of Leptin and Calpain/Calpastatin in Key Traits of Pork Meat Quality.Animals : an open access journal from MDPI · 2025Review
- Evaluating regional heritability mapping methods for identifying QTLs in a wild population of Soay sheep.Heredity · 2025Article
- Lipid Droplet-Derived Biomimetic Nanocarriers for the Enhancement of Porcine Intermuscular Fat Content.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Association between mitochondrial DNA copy number and production traits in pigs.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Genome-Wide Association Study Reveals Single Nucleotide Polymorphisms Associated with Tail Length and Tail Kinks in Piglets.Veterinary sciences · 2025Article
- Candidate genes associated with fatty acid compositions in north American Atlantic salmon (Salmo salar).BMC genomics · 2024Article
- Identification of genomic regions associated with fatty acid metabolism across blood, liver, backfat and muscle in pigs.Genetics, selection, evolution : GSE · 2024Article
- Impact of the leptin receptor gene on pig performance and quality traits.Scientific reports · 2024Article
- Transcriptome and Metabolome Analyses Provide Insight into the Glucose-Induced Adipogenesis in Porcine Adipocytes.Current issues in molecular biology · 2024Article
- Integrative Analysis of Transcriptomic and Lipidomic Profiles Reveals a Differential Subcutaneous Adipose Tissue Mechanism among Ningxiang Pig and Berkshires, and Their Offspring.Animals : an open access journal from MDPI · 2023Article
- Regulation of omega-3 fatty acids production by different genes in freshwater fish species: a review.Fish physiology and biochemistry · 2023Review
- Genome-Wide Association Study of Maternal Genetic Effects on Intramuscular Fat and Fatty Acid Composition in Rabbits.Animals : an open access journal from MDPI · 2023Article
- Identification of breed-specific genomic variants in Colombian Creole pig breeds by whole-genome sequencing.Tropical animal health and production · 2023Article
- Multi-tissue transcriptome analysis to identify candidate genes associated with weight regulation in Hanwoo cattle.Frontiers in genetics · 2023Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intramuscular fat (IMF) content and fatty acid composition affect the organoleptic quality and nutritional value of pork. A genome-wide association study was performed on 138 Duroc pigs genotyped with a 60k SNP chip to detect biologically relevant genomic variants influencing fat content and composition. Despite the limited sample size, the genome-wide association study was powerful enough to detect the association between fatty acid composition and a known haplotypic variant in SCD (SSC14) and to reveal an association of IMF and fatty acid composition in the LEPR region (SSC6). The association of LEPR was later validated with an independent set of 853 pigs using a candidate quantitative trait nucleotide. The SCD gene is responsible for the biosynthesis of oleic acid (C18:1) from stearic acid. This locus affected the stearic to oleic desaturation index (C18:1/C18:0), C18:1, and saturated (SFA) and monounsaturated (MUFA) fatty acids content. These effects were consistently detected in gluteus medius, longissimus dorsi, and subcutaneous fat. The association of LEPR with fatty acid composition was detected only in muscle and was, at least in part, a consequence of its effect on IMF content, with increased IMF resulting in more SFA, less polyunsaturated fatty acids (PUFA), and greater SFA/PUFA ratio. Marker substitution effects estimated with a subset of 65 animals were used to predict the genomic estimated breeding values of 70 animals born 7 years later. Although predictions with the whole SNP chip information were in relatively high correlation with observed SFA, MUFA, and C18:1/C18:0 (0.48-0.60), IMF content and composition were in general better predicted by using only SNPs at the SCD and LEPR loci, in which case the correlation between predicted and observed values was in the range of 0.36 to 0.54 for all traits. Results indicate that markers in the SCD and LEPR genes can be useful to select for optimum fatty acid profiles of pork.
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