ArticlePloS one2016
High-Speed Video-Oculography for Measuring Three-Dimensional Rotation Vectors of Eye Movements in Mice.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 29 citations in OpenAlex.
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- Evaluation of the vestibulo-ocular reflex in head-tilt mutant mice.Biochemistry and biophysics reports · 2025Article
- Efficacy of the silicon based agent for age related decline in vestibular function.Scientific reports · 2025Article
- Effects of aging on otolith morphology and functions in mice.Frontiers in neuroscience · 2024Article
- Improving Performance of the Human Pupil Orbit Model (HPOM) Estimation Method for Eye-Gaze Tracking.Sensors (Basel, Switzerland) · 2022Article
- Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex.Scientific reports · 2021Article
- Effect of Sitting Position vs. Supine Position With the Head Turned to the Affected Side on Benign Paroxysmal Positional Vertigo Fatigue.Frontiers in neurology · 2021Article
- Quantitative Assessment of Anti-Gravity Reflexes to Evaluate Vestibular Dysfunction in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Vestibular Compensation after Vestibular Dysfunction Induced by Arsanilic Acid in Mice.Brain sciences · 2019Article
- Recovery of positional nystagmus after benign paroxysmal positional vertigo fatigue.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Observational
- Visual Target Strategies in Infantile Nystagmus Patients With Horizontal Jerk Waveform.Frontiers in neurology · 2018Article
- Article
- Three-dimensional analysis of linear vestibulo-ocular reflex in humans during eccentric rotation while facing downwards.Experimental brain research · 2017Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mouse is the most commonly used animal model in biomedical research because of recent advances in molecular genetic techniques. Studies related to eye movement in mice are common in fields such as ophthalmology relating to vision, neuro-otology relating to the vestibulo-ocular reflex (VOR), neurology relating to the cerebellum's role in movement, and psychology relating to attention. Recording eye movements in mice, however, is technically difficult.
methodsWe developed a new algorithm for analyzing the three-dimensional (3D) rotation vector of eye movement in mice using high-speed video-oculography (VOG). The algorithm made it possible to analyze the gain and phase of VOR using the eye's angular velocity around the axis of eye rotation.
resultsWhen mice were rotated at 0.5 Hz and 2.5 Hz around the earth's vertical axis with their heads in a 30° nose-down position, the vertical components of their left eye movements were in phase with the horizontal components. The VOR gain was 0.42 at 0.5 Hz and 0.74 at 2.5 Hz, and the phase lead of the eye movement against the turntable was 16.1° at 0.5 Hz and 4.88° at 2.5 Hz.
conclusionsTo the best of our knowledge, this is the first report of this algorithm being used to calculate a 3D rotation vector of eye movement in mice using high-speed VOG. We developed a technique for analyzing the 3D rotation vector of eye movements in mice with a high-speed infrared CCD camera. We concluded that the technique is suitable for analyzing eye movements in mice. We also include a C++ source code that can calculate the 3D rotation vectors of the eye position from two-dimensional coordinates of the pupil and the iris freckle in the image to this article.
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