ArticlePloS one2016
Hypomagnesemia Is Associated with Increased Mortality among Peritoneal Dialysis Patients.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
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The trial behind it
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Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Pooled it
- Risk factors for mortality in patients undergoing peritoneal dialysis: a systematic review and meta-analysis.Renal failure · 2021Pooled it
- Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review.Nutrients · 2021Pooled it
- Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.Journal of nephrology · 2019Pooled it
- Association between dietary magnesium intake and all-cause mortality in patients with chronic kidney disease: Insights from NHANES 1999-2018.Clinical medicine (London, England) · 2026Article
- Review
- Hypomagnesemia in peritoneal and hybrid dialysis: prevalence, predictors, and association with atrial fibrillation.Clinical and experimental nephrology · 2026Article
- The impact of low serum and dialysate magnesium levels on clinical outcomes in peritoneal dialysis patients: a literature review.BMC nephrology · 2025Review
- Article
- Association Between Serum Magnesium Levels and Depression in Patients Undergoing Peritoneal Dialysis: A Study Conducted at Handan First Hospital, China.Psychology research and behavior management · 2024Article
- Review
- Lower serum magnesium is a predictor of left ventricular hypertrophy in patients on dialysis.International urology and nephrology · 2023Article
- Magnesium to prevent kidney disease-associated vascular calcification: crystal clear?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Influencing factors of serum magnesium in CKD5 patients: A multicenter study in southern China.Frontiers in public health · 2022Article
- Low plasma magnesium concentration and future abdominal aortic calcifications in moderate chronic kidney disease.BMC nephrology · 2021Article
- Review
- Hypomagnesemia and Short-Term Mortality in Elderly Maintenance Hemodialysis Patients.Kidney diseases (Basel, Switzerland) · 2020Article
- Triglyceride to high-density lipoprotein cholesterol ratio is associated with increased mortality in older patients on peritoneal dialysis.Lipids in health and disease · 2019Article
- Review
- Clearance of Magnesium in Peritoneal Dialysis Patients: A Single-Center Study.Blood purification · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHypomagnesemia has been associated with an increase in mortality among the general population as well as patients with chronic kidney disease or those on hemodialysis. However, this association has not been thoroughly studied in patients undergoing peritoneal dialysis. The aim of this study was to evaluate the association between serum magnesium concentrations and all-cause and cardiovascular mortalities in peritoneal dialysis patients.
methodsThis single-center retrospective study included 253 incident peritoneal dialysis patients enrolled between July 1, 2005 and December 31, 2014 and followed to June 30, 2015. Patient's demographic characteristics as well as clinical and laboratory measurements were collected.
resultsOf 253 patients evaluated, 36 patients (14.2%) suffered from hypomagnesemia. During a median follow-up of 29 months (range: 4-120 months), 60 patients (23.7%) died, and 35 (58.3%) of these deaths were attributed to cardiovascular causes. Low serum magnesium was positively associated with peritoneal dialysis duration (r = 0.303, p < 0.001) as well as serum concentrations of albumin (r = 0.220, p < 0.001), triglycerides (r = 0.160, p = 0.011), potassium (r = 0.156, p = 0.013), calcium(r = 0.299, p < 0.001)and phosphate (r = 0.191, p = 0.002). Patients in the hypomagnesemia group had a lower survival rate than those in the normal magnesium groups (p < 0.001). In a multivariate Cox proportional hazards regression analysis, serum magnesium was an independent negative predictor of all-cause mortality (hazard ratio [HR] = 0.075, p = 0.011) and cardiovascular mortality (HR = 0.003, p < 0.001), especially in female patients. However, in univariate and multivariate Cox analysis, △Mg(difference between 1-year magnesium and baseline magnesium) was not an independent predictor of all-cause mortality and cardiovascular mortality.
conclusionHypomagnesemia was common among peritoneal dialysis patients and was independently associated with all-cause mortality and cardiovascular mortality.
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