Evidence map›Paper›PMID 27023616›Full record

ReviewLife (Basel, Switzerland)2016

Multiple Layers of Stress-Induced Regulation in tRNA Biology.

Hsiao-Yun Huang, Anita K Hopper

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. tRNA modifications in viral replication.The Journal of biological chemistry · 2026
    Review
  5. Article
  6. Review
  7. tRNA Modifications: A Tale of Two Viruses-SARS-CoV-2 and ZIKV.International journal of molecular sciences · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  16. Article
  17. A tRNA modification inbioRxiv : the preprint server for biology · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hsiao-Yun HuangDepartment of Biology, Indiana University, 915 E third St., Myers 300, Bloomington, IN 47405, USA. hh24@indiana.edu.
Anita K HopperDepartment of Molecular Genetics and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA. hopper.64@osu.edu.
Indiana University Bloomington · USThe Ohio State University · US

Funding

YEAST GENES IN RNA PROCESSING &NUCLEUS/CYTOSOL EXCHANGER01GM027930 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HOPPER, ANITA K · 1985 to 2014
$4.6M
NIGMS NIH HHS R01 GM027930
6 · The paper itself

Abstract

tRNAs are the fundamental components of the translation machinery as they deliver amino acids to the ribosomes during protein synthesis. Beyond their essential function in translation, tRNAs also function in regulating gene expression, modulating apoptosis and several other biological processes. There are multiple layers of regulatory mechanisms in each step of tRNA biogenesis. For example, tRNA 3' trailer processing is altered upon nutrient stress; tRNA modification is reprogrammed under various stresses; nuclear accumulation of tRNAs occurs upon nutrient deprivation; tRNA halves accumulate upon oxidative stress. Here we address how environmental stresses can affect nearly every step of tRNA biology and we describe the possible regulatory mechanisms that influence the function or expression of tRNAs under stress conditions.

Indexed as

tRNA fragmentstRNA modificationtRNA processingtRNA subcellular dynamics

Identifiers

PMID27023616
PMCPMC4931453
OpenAlexW2310645967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.