ArticleInternational journal of environmental research and public health2016
Salivary Alpha-Amylase Reactivity in Breast Cancer Survivors.
Article in International journal of environmental research and public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The Effects of Light Therapy on Cognitive Function and Stress in Women With Breast Cancer Before Systemic Treatment.Cancer medicine · 2025Trial
- Characteristics of salivary cortisol and alpha-amylase as psychobiological study outcomes in palliative care research.BMC palliative care · 2022Trial
- Psychoneuroendocrinological effects of music therapy versus mindfulness in palliative care: results from the 'Song of Life' randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Trial
- The Effect of Continuous Intake ofNutrients · 2021Trial
- Trial
- Observational
- The associations of spirituality and Hispanic ethnicity with neuroendocrine biomarkers among patients with colorectal cancer.Journal of psychosomatic research · 2024Observational
- Biological and psychological predictors of cognitive function in breast cancer patients before surgery.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- The independent association between salivary alpha-amylase activity and arterial stiffness in Japanese men and women: the Toon Health Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Alpha-Amylase Inhibits Cell Proliferation and Glucose Uptake in Human Neuroblastoma Cell Lines.BioMed research international · 2022Article
- Associations between religious and spiritual variables and neuroimmune activity in survivors of breast cancer: a feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Salivary Alpha-Amylase in Experimentally-Induced Muscle Pain.Diagnostics (Basel, Switzerland) · 2020Article
- Protein Signature in Saliva of Temporomandibular Disorders Myalgia.International journal of molecular sciences · 2020Article
- Relationship between Personality and Biological Reactivity to Stress: A Review.Psychiatry investigation · 2018Article
- Salivary secretory immunoglobulin A reactivity: a comparison to cortisol and α-amylase patterns in the same breast cancer survivors.Contemporary oncology (Poznan, Poland) · 2018Article
- Rural-Urban Differences in Neuroimmune Biomarkers and Health Status Among Women Living With Breast Cancer.Cancer nursingArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The two main components of the stress system are the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal-medullary (SAM) axes. While cortisol has been commonly used as a biomarker of HPA functioning, much less attention has been paid to the role of the SAM in this context. Studies have shown that long-term breast cancer survivors display abnormal reactive cortisol patterns, suggesting a dysregulation of their HPA axis. To fully understand the integrity of the stress response in this population, this paper explored the diurnal and acute alpha-amylase profiles of 22 breast cancer survivors and 26 women with no history of cancer. Results revealed that breast cancer survivors displayed identical but elevated patterns of alpha-amylase concentrations in both diurnal and acute profiles relative to that of healthy women, F (1, 39) = 17.95, p < 0.001 and F (1, 37) = 7.29, p = 0.010, respectively. The average area under the curve for the diurnal and reactive profiles was 631.54 ± 66.94 SEM and 1238.78 ± 111.84 SEM, respectively. This is in sharp contrast to their cortisol results, which showed normal diurnal and blunted acute patterns. The complexity of the stress system necessitates further investigation to understand the synergistic relationship of the HPA and SAM axes.
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