ArticleJournal of visualized experiments : JoVE2016
A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology.
Article in Journal of visualized experiments : JoVE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Loss of Sarm1 Mitigates Axonal Degeneration and Promotes Neuronal Repair After Ischemic Stroke.bioRxiv : the preprint server for biology · 2025Article
- Rodent ischemic stroke models and their relevance in preclinical research.Neuroprotection (Chichester, England) · 2024Review
- Subcortical White Matter Stroke in the Mouse: Inducing Injury and Tracking Cellular Proliferation.Methods in molecular biology (Clifton, N.J.) · 2023Article
- IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury.Cell reports · 2022Article
- Casein Kinase 2 Signaling in White Matter Stroke.Frontiers in molecular biosciences · 2022Review
- Differential Role of p53 in Oligodendrocyte Survival in Response to Various Stresses: Experimental Autoimmune Encephalomyelitis, Cuprizone Intoxication or White Matter Stroke.International journal of molecular sciences · 2021Article
- Endothelial Nitric Oxide Synthase-Deficient Mice: A Model of Spontaneous Cerebral Small-Vessel Disease.The American journal of pathology · 2021Review
- Conditioning medicine for ischemic and hemorrhagic stroke.Conditioning medicine · 2021Article
- Modeling subcortical ischemic white matter injury in rodents: unmet need for a breakthrough in translational research.Neural regeneration research · 2021Article
- Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions.Nature communications · 2020Article
- Modeling Mixed Vascular and Alzheimer's Dementia Using Focal Subcortical Ischemic Stroke in Human ApoE4-TR:5XFAD Transgenic Mice.Translational stroke research · 2020Article
- Distinctive functional deficiencies in axonal conduction associated with two forms of cerebral white matter injury.CNS neuroscience & therapeutics · 2019Article
- Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation.Acta neuropathologica communications · 2019Article
- The effect of age-related risk factors and comorbidities on white matter injury and repair after ischemic stroke.Neurobiology of disease · 2019Review
- Stroke in CNS white matter: Models and mechanisms.Neuroscience letters · 2018Review
- Concepts and opportunities for repair in cerebral microvascular disease and white matter stroke.Neural regeneration research · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Stroke affecting white matter accounts for up to 25% of clinical stroke presentations, occurs silently at rates that may be 5-10 fold greater, and contributes significantly to the development of vascular dementia. Few models of focal white matter stroke exist and this lack of appropriate models has hampered understanding of the neurobiologic mechanisms involved in injury response and repair after this type of stroke. The main limitation of other subcortical stroke models is that they do not focally restrict the infarct to the white matter or have primarily been validated in non-murine species. This limits the ability to apply the wide variety of murine research tools to study the neurobiology of white matter stroke. Here we present a methodology for the reliable production of a focal stroke in murine white matter using a local injection of an irreversible eNOS inhibitor. We also present several variations on the general protocol including two unique stereotactic variations, retrograde neuronal tracing, as well as fresh tissue labeling and dissection that greatly expand the potential applications of this technique. These variations allow for multiple approaches to analyze the neurobiologic effects of this common and understudied form of stroke.
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Registered trials
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