Evidence map›Paper›PMID 27023224›Full record

ArticleMolecular neurobiology2017

Association of DISC1 Polymorphisms with Late-Onset Alzheimer's Disease in Northern Han Chinese.

Xiao-Yan Zhang, Hui-Fu Wang, Meng-Shan Tan, Yu Wan, Ling-Li Kong, Zhan-Jie Zheng, Chen-Chen Tan, Wei Zhang, Zi-Xuan Wang, Lin Tan and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Xiao-Yan ZhangDepartment of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, People's Republic of China.
Hui-Fu WangDepartment of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, People's Republic of China.
Meng-Shan TanDepartment of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, People's Republic of China.
Yu WanDepartment of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, People's Republic of China.
Ling-Li KongDepartment of Geriatric, Qingdao Mental Health Center, Qingdao, 266034, China.
Zhan-Jie ZhengDepartment of Geriatric, Qingdao Mental Health Center, Qingdao, 266034, China.
Chen-Chen TanDepartment of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, People's Republic of China.
Wei ZhangDepartment of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, People's Republic of China.
Zi-Xuan WangDepartment of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, People's Republic of China.
Lin TanCollege of Medicine and Pharmaceutics, Ocean University of China, Qingdao, 266000, China.
Teng JiangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
Lan TanDepartment of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, People's Republic of China. dr.tanlan@163.com.
Jin-Tai YuDepartment of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, People's Republic of China. yu-jintai@163.com.
Qingdao University · CNNanjing Medical University · CNQingdao Mental Health Center · CNOcean University of China · CNQingdao Municipal Hospital · CNUniversity Memory and Aging Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The disrupted-in-schizophrenia-1 (DISC1) is a candidate gene for psychiatric diseases and plays various roles in brain development. It has been reported as a candidate gene for Alzheimer's disease (AD) in a recent large genome-wide association study in Caucasians. To explore the associations between DISC1 and AD, we performed a case-control study including 2318 subjects in Northern Han Chinese. We found that one single nucleotide polymorphism (rs6675281) was associated with the risk of late-onset Alzheimer's disease (LOAD) in northern Han Chinese population. As for rs821616 and rs3738401, no association was detected with LOAD. In conclusion, DISC1 increased the risk for LOAD in northern Han Chinese population.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAgedAge of OnsetAllelesAlzheimer DiseaseAnimalsAsian PeopleEthnicityFemaleGene FrequencyHominidaeHumansLogistic ModelsMaleNerve Tissue ProteinsDISC1 protein, humanNerve Tissue ProteinsAlzheimer’s diseaseAssociationDISC1Polymorphism

Identifiers

PMID27023224
OpenAlexW2324543880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.