ArticlePLoS neglected tropical diseases2016
Allicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Allicin-based biomimetic nanoparticles of the erythrocyte membrane for the delivery of lumefantrine to enhance its antimalarial effect.International journal of pharmaceutics: X · 2026Article
- Anthelmintic Activity and Pathophysiological Effect ofJournal of parasitology research · 2025Article
- Synthesis of a dehydrodieugenol B derivative as a lead compound for visceral leishmaniasis-mechanism of action andAntimicrobial agents and chemotherapy · 2024Article
- Toward New Therapeutics for Visceral Leishmaniasis: Efficacy and Mechanism of Action of Amides Inspired by Gibbilimbol B.ACS omega · 2024Article
- Novel Schiff bases of Vanillin: potent inhibitors of macrophage harboredJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Anti-Tropical medicine and infectious disease · 2023Article
- Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance inLife (Basel, Switzerland) · 2023Article
- New Insights into the Mechanism of Action of the Cyclopalladated Complex (CP2) inAntimicrobial agents and chemotherapy · 2022Article
- Metalloprotease Gp63-Targeting Novel Glycoside Exhibits Potential Antileishmanial Activity.Frontiers in cellular and infection microbiology · 2022Article
- Total Phenolic Fraction (TPF) from Extra Virgin Olive Oil: Induction of apoptotic-like cell death in Leishmania spp. promastigotes and in vivo potential of therapeutic immunomodulation.PLoS neglected tropical diseases · 2021Article
- Bioassay-based Corchorus capsularis L. leaf-derived β-sitosterol exerts antileishmanial effects against Leishmania donovani by targeting trypanothione reductase.Scientific reports · 2020Article
- Review: antimicrobial properties of allicin used alone or in combination with other medications.Folia microbiologica · 2020Review
- Antileishmanial Activity and Synergistic Effects of Amphotericin B Deoxycholate with Allicin and Andrographolide againstPathogens (Basel, Switzerland) · 2020Article
- Article
- CGA-N12, a peptide derived from chromogranin A, promotes apoptosis ofThe Biochemical journal · 2018Article
- Activity of Thioallyl Compounds From Garlic AgainstFrontiers in cellular and infection microbiology · 2018Article
- Article
- Synthesis and in vitro biological evaluation of thiosulfinate derivatives for the treatment of human multidrug-resistant breast cancer.Acta pharmacologica Sinica · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAllicin has shown antileishmanial activity in vitro and in vivo. However the mechanism of action underlying its antiproliferative effect against Leishmania has been virtually unexplored. In this paper, we present the results obtained in L.infantum and a mechanistic basis is proposed. METHODOLOGY/PRINCIPAL FINDING: Exposure of the parasites to allicin led to high Ca2+ levels and mitochondrial reactive oxygen species (ROS), collapse of the mitochondrial membrane potential, reduced production of ATP and elevation of cytosolic ROS. The incubation of the promastigotes with SYTOX Green revealed that decrease of ATP was not associated with plasma membrane permeabilization. Annexin V and propidium iodide (PI) staining indicated that allicin did not induce phospholipids exposure on the plasma membrane. Moreover, DNA agarose gel electrophoresis and TUNEL analysis demonstrated that allicin did not provoke DNA fragmentation. Analysis of the cell cycle with PI staining showed that allicin induced cell cycle arrest in the G2/M phase. CONCLUSIONS/SIGNIFICANCE: We conclude that allicin induces dysregulation of calcium homeostasis and oxidative stress, uncontrolled by the antioxidant defense of the cell, which leads to mitochondrial dysfunction and a bioenergetic catastrophe leading to cell necrosis and cell cycle arrest in the premitotic phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.