ArticleThe ISME journal2016
Differences down-under: alcohol-fueled methanogenesis by archaea present in Australian macropodids.
Article in The ISME journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Early life treatment with Lacticaseibacillus rhamnosus strains drives reduced enteric methane emissions in dairy heifers.Journal of animal science and biotechnology · 2026Article
- Metagenomic analysis of fecal microbiomes reveals genetic potential for diverse hydrogen management strategies in marsupials.mSystems · 2026Article
- Multi-kingdom fecal microbiome and virus-host interactions associated with growth performance of indigenous beef calves in Guizhou.BMC microbiology · 2026Article
- Disrupting the mtr-operon in Methanosarcina acetivorans enables methyl-reducing methanogenesis with hydrogen and serine as the alternative electron donors.FEMS microbiology letters · 2026Article
- Article
- Isolation of aFrontiers in microbiology · 2024Article
- Integrating Omics Technologies for a Comprehensive Understanding of the Microbiome and Its Impact on Cattle Production.Biology · 2023Review
- Novel complete methanogenic pathways in longitudinal genomic study of monogastric age-associated archaea.Animal microbiome · 2023Article
- Isolation and characterisation of novel Methanocorpusculum species indicates the genus is ancestrally host-associated.BMC biology · 2023Article
- Methyl-Based Methanogenesis: an Ecological and Genomic Review.Microbiology and molecular biology reviews : MMBR · 2023Review
- Competitive Reactions during Ethanol Chain Elongation Were Temporarily Suppressed by Increasing Hydrogen Partial Pressure through Methanogenesis Inhibition.Environmental science & technology · 2023Article
- The evolving role of methanogenic archaea in mammalian microbiomes.Frontiers in microbiology · 2023Review
- Article
- Ecology of Methanonatronarchaeia.Environmental microbiology · 2022Article
- A catalogue of 1,167 genomes from the human gut archaeome.Nature microbiology · 2022Article
- The rumen microbiome inhibits methane formation through dietary choline supplementation.Scientific reports · 2021Article
- Several ways one goal-methanogenesis from unconventional substrates.Applied microbiology and biotechnology · 2020Review
- Comparative Microbiome Analysis Reveals the Ecological Relationships Between Rumen Methanogens, Acetogens, and Their Hosts.Frontiers in microbiology · 2020Article
- Energy Conservation and Hydrogenase Function in Methanogenic Archaea, in Particular the GenusMicrobiology and molecular biology reviews : MMBR · 2019Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Australian macropodids (kangaroos and wallabies) possess a distinctive foregut microbiota that contributes to their reduced methane emissions. However, methanogenic archaea are present within the macropodid foregut, although there is scant understanding of these microbes. Here, an isolate taxonomically assigned to the Methanosphaera genus (Methanosphaera sp. WGK6) was recovered from the anterior sacciform forestomach contents of a Western grey kangaroo (Macropus fuliginosus). Like the human gut isolate Methanosphaera stadtmanae DSMZ 3091(T), strain WGK6 is a methylotroph with no capacity for autotrophic growth. In contrast, though with the human isolate, strain WGK6 was found to utilize ethanol to support growth, but principally as a source of reducing power. Both the WGK6 and DSMZ 3091(T) genomes are very similar in terms of their size, synteny and G:C content. However, the WGK6 genome was found to encode contiguous genes encoding putative alcohol and aldehyde dehydrogenases, which are absent from the DSMZ 3091(T) genome. Interestingly, homologs of these genes are present in the genomes for several other members of the Methanobacteriales. In WGK6, these genes are cotranscribed under both growth conditions, and we propose the two genes provide a plausible explanation for the ability of WGK6 to utilize ethanol for methanol reduction to methane. Furthermore, our in vitro studies suggest that ethanol supports a greater cell yield per mol of methane formed compared to hydrogen-dependent growth. Taken together, this expansion in metabolic versatility can explain the persistence of these archaea in the kangaroo foregut, and their abundance in these 'low-methane-emitting' herbivores.
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