Evidence map›Paper›PMID 27022858›Full record

ArticleRadiology2016

MR Imaging Measures of Intracranial Atherosclerosis in a Population-based Study.

Ye Qiao, Eliseo Guallar, Fareed K Suri, Li Liu, Yiyi Zhang, Zeeshan Anwar, Saeedeh Mirbagheri, YuanYuan Joyce Xie, Nariman Nezami, Jarunee Intrapiromkul and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. MR Intracranial Vessel Wall Imaging: A Systematic Review.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020
    Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Accurate and fully automated diameter measurements of Circle of Willis arteries on MRA imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  14. Article
  15. Review
  16. High resolution 7T MR imaging in characterizing culprit intracranial atherosclerotic plaques.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ye QiaoFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Eliseo GuallarFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Fareed K SuriFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Li LiuFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Yiyi ZhangFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Zeeshan AnwarFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Saeedeh MirbagheriFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
YuanYuan Joyce XieFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Nariman NezamiFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Jarunee IntrapiromkulFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Shuqian ZhangFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Alvaro AlonsoFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Haitao ChuFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
David CouperFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).
Bruce A WassermanFrom The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287 (Y.Q., L.L., Z.A., S.M., Y.J.X., N.N., J.I., S.Z., B.A.W.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (E.G., Y.Z.); Department of Neurology, University of Minnesota, Minneapolis, Minn (F.K.S.); School of Public Health, University of Minnesota, Minneapolis, Minn (A.A., H.C.); School of Public Health, University of North Carolina, Chapel Hill, NC (D.C.).

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
The ARIC and Neurocognitive Longitudinal StudyR01HL070825 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI MOSLEY, THOMAS H · 2002 to 2004
$5.1M
The Intracranial Atherosclerotic Disease and Cognitive Impairment StudyR01HL105930 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SURI, MUHAMMAD FAREED, WASSERMAN, BRUCE A · 2011 to 2014
$2.7M
The Intracranial Atherosclerotic Disease and Cognitive Impairment StudyR01HL105626 · NHLBI · UNIVERSITY OF MINNESOTA · PI SURI, MUHAMMAD FAREED, WASSERMAN, BRUCE A · 2011 to 2014
$1.3M
MRI of Intracranial AtherosclerosisR00HL106232 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI QIAO, YE · 2014 to 2016
$739k
MRI of Intracranial AtherosclerosisK99HL106232 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI QIAO, YE · 2012 to 2013
$177k
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS K99 HL106232NHLBI NIH HHS R00 HL106232NHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01 HL105626NHLBI NIH HHS R01 HL105930NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917
6 · The paper itself

Abstract

Purpose To implement a magnetic resonance (MR) imaging protocol to measure intracranial atherosclerotic disease (ICAD) in a population-based multicenter study and report examination and reader reliability of these MR imaging measurements and descriptive statistics representative of the general population. Materials and Methods This prospective study was approved by the institutional review boards and compliant with HIPAA. Atherosclerosis Risk in Communities (ARIC) study participants (n = 1980) underwent brain MR imaging from 2011 to 2013 at four ARIC sites. Imaging included three-dimensional black-blood MR imaging and time-of-flight MR angiography. One hundred two participants returned for repeat MR imaging to estimate examination and reader variability. Plaque presence according to vessel segment was recorded. Quantitative measurements included lumen size and degree of stenosis, wall and/or plaque thickness, area and volume, and normalized wall index for each vessel segment. Reliability was assessed with percentage agreement, κ statistics, and intraclass correlation coefficients. Results Of the 1980 participants, 1755 (mean age, 77.6 years; 1026 women [59%]; 1234 white [70%]) completed examinations with adequate to excellent image quality. The weighted ICAD prevalence was 34.4% (637 of 1755 participants) and was higher in men than women (38.5% [302 of 729 participants] vs 31.7% [335 of 1026 participants], respectively; P = .012) and in African Americans compared with whites (41.1% [215 of 518 participants] vs 32.4% [422 of 1234 participants], respectively; P = .002). Percentage agreement of plaque identification per participant was 87.0% (interreader estimate), 89.2% (intrareader estimate), and 89.9% (examination estimate). Examination and reader reliability ranged from fair to good (κ, 0.50-0.78) for plaque presence and from good to excellent (intraclass correlation coefficient, 0.69-0.99) for quantitative vessel wall measurements. Conclusion Vessel wall MR imaging is a reliable tool for identifying and measuring ICAD and provided insight into ICAD distribution across a U.S. community-based population. (©) RSNA, 2016 Online supplemental material is available for this article.

Indexed as

AgedFemaleHumansImage Interpretation, Computer-AssistedIntracranial ArteriosclerosisMagnetic Resonance ImagingMaleProspective StudiesReproducibility of Results

Identifiers

PMID27022858
PMCPMC5006718

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