Evidence map›Paper›PMID 27022681›Full record

ArticleJournal of visualized experiments : JoVE2016

Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles.

C Wyatt Shields, Daniela F Cruz, Korine A Ohiri, Benjamin B Yellen, Gabriel P Lopez

Abstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

C Wyatt ShieldsNSF Research Triangle Materials Research Science and Engineering Center, Duke University; Department of Biomedical Engineering, Duke University.
Daniela F CruzNSF Research Triangle Materials Research Science and Engineering Center, Duke University; Department of Biomedical Engineering, Duke University.
Korine A OhiriNSF Research Triangle Materials Research Science and Engineering Center, Duke University; Department of Mechanical Engineering and Materials Science, Duke University.
Benjamin B YellenNSF Research Triangle Materials Research Science and Engineering Center, Duke University; Department of Biomedical Engineering, Duke University; Department of Mechanical Engineering and Materials Science, Duke University.
Gabriel P LopezNSF Research Triangle Materials Research Science and Engineering Center, Duke University; Department of Biomedical Engineering, Duke University; Department of Mechanical Engineering and Materials Science, Duke University; gabriel.lopez@duke.edu.
Duke University · US

Funding

An Instrument for Negative Acoustic Contrast Bead-based Cell Sorting and StainingR21GM111584 · NIGMS · DUKE UNIVERSITY · PI YELLEN, BENJAMIN BIRON · 2014 to 2016
$544k
NIGMS NIH HHS R21 GM111584NIGMS NIH HHS R21GM111584
6 · The paper itself

Abstract

Acoustophoresis refers to the displacement of suspended objects in response to directional forces from sound energy. Given that the suspended objects must be smaller than the incident wavelength of sound and the width of the fluidic channels are typically tens to hundreds of micrometers across, acoustofluidic devices typically use ultrasonic waves generated from a piezoelectric transducer pulsating at high frequencies (in the megahertz range). At characteristic frequencies that depend on the geometry of the device, it is possible to induce the formation of standing waves that can focus particles along desired fluidic streamlines within a bulk flow. Here, we describe a method for the fabrication of acoustophoretic devices from common materials and clean room equipment. We show representative results for the focusing of particles with positive or negative acoustic contrast factors, which move towards the pressure nodes or antinodes of the standing waves, respectively. These devices offer enormous practical utility for precisely positioning large numbers of microscopic entities (e.g., cells) in stationary or flowing fluids for applications ranging from cytometry to assembly.

Indexed as

NanoparticlesCell SeparationMicrofluidicsSonicationSound

Identifiers

PMID27022681
PMCPMC4828217
OpenAlexW2289565023

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.