Evidence map›Paper›PMID 27022485›Full record

ArticleJournal of pathogens2016

Encephalitozoon cuniculi: Grading the Histological Lesions in Brain, Kidney, and Liver during Primoinfection Outbreak in Rabbits.

Luis E Rodríguez-Tovar, Alicia M Nevárez-Garza, Armando Trejo-Chávez, Carlos A Hernández-Martínez, Gustavo Hernández-Vidal, Juan J Zarate-Ramos, Uziel Castillo-Velázquez

Open access · hybridAbstract read
In one paragraph

Article in Journal of pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Chemical disinfection ofFrontiers in microbiology · 2025
    Article
  3. Occurrence ofAnimals : an open access journal from MDPI · 2024
    Article
  4. Diseases of domestic rabbits by purpose; a retrospective study of 2,583 cases received at 4 diagnostic laboratories in California, USA, 2013-2022.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024
    Article
  5. Article
  6. Chronic Infections in Mammals Due to Microsporidia.Experientia supplementum (2012) · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Luis E Rodríguez-TovarCuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, Calle Francisco Villa s/n, Ex-Hacienda El Canadá, 66050 Escobedo, NL, Mexico.
Alicia M Nevárez-GarzaCuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, Calle Francisco Villa s/n, Ex-Hacienda El Canadá, 66050 Escobedo, NL, Mexico.
Armando Trejo-ChávezCuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, Calle Francisco Villa s/n, Ex-Hacienda El Canadá, 66050 Escobedo, NL, Mexico.
Carlos A Hernández-MartínezCuerpo Académico de Nutrición y Forrajes, Facultad de Agronomía, Universidad Autónoma de Nuevo León, Calle Francisco Villa s/n, Ex-Hacienda El Canadá, 66050 Escobedo, NL, Mexico.
Gustavo Hernández-VidalCuerpo Académico de Patobiología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, Calle Francisco Villa s/n, Ex-Hacienda El Canadá, 66050 Escobedo, NL, Mexico.ORCID 0000-0002-6229-5655
Juan J Zarate-RamosCuerpo Académico de Epidemiología Veterinaria, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, Calle Francisco Villa s/n, Ex-Hacienda El Canadá, 66050 Escobedo, NL, Mexico.
Uziel Castillo-VelázquezCuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, Calle Francisco Villa s/n, Ex-Hacienda El Canadá, 66050 Escobedo, NL, Mexico.
Universidad Autónoma de Nuevo León · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This is the first confirmed report of Encephalitozoon cuniculi (E. cuniculi) in farm meat rabbits located in Northern Mexico. Eighty young rabbits exhibited clinical signs of this zoonotic emerging disease, like torticollis, ataxia, paresis, circling, and rolling. Samples of brain, kidney, and liver were examined for histology lesions. For the first time the lesions caused by E. cuniculi were graded according to their severity (I, II, and III) and the size of the granulomas (Types A, B, and C). The main cerebral injuries were Grade III, coinciding with the presence of Type C granulomas. The cerebral lesions were located in the cortex, brain stem, and medulla. The renal lesions were also Grade III distributed throughout cortex and renal medulla, with no granuloma formation. The involvement of hypersensitivity Types III and IV is suggested. All of the rabbits were seropositive to E. cuniculi by CIA testing, suggesting that this zoonotic and emerging pathogen is widely distributed among animals intended for human consumption. We believe this work could be used as a guide when examining E. cuniculi and will provide direction to confirm the diagnosis of this pathogen.

Identifiers

PMID27022485
PMCPMC4789044
OpenAlexW2273883095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.