ReviewWorld journal of diabetes2016
Low serum amylase and obesity, diabetes and metabolic syndrome: A novel interpretation.
Review in World journal of diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 71 citations in OpenAlex.
- Trial
- Serum and Salivary Amylase Variations During Exercise Testing in Athletes and Their Correlation with Cardiovascular Parameters-A Pilot Study.Medicina (Kaunas, Lithuania) · 2026Article
- The Intestinal Mechanisms in the Excretion of Pepsinogen, Amylase and Lipase in Coprofiltrate in Women During Pregnancy and the Postpartum Period.Biomolecules · 2025Article
- Effects of tea polysaccharides on gut microbiota and physiological health indicators in mice.Scientific reports · 2025Article
- A new model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine.Basic research in cardiology · 2025Article
- The role of AMY1 gene copy number variation in dental caries susceptibility: insights from a Turkish population.BMC oral health · 2025Article
- Article
- Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test, proof of acini-islet-acinar interactions.World journal of experimental medicine · 2024Article
- Improvement effect of gemigliptin on salivary gland dysfunction in exogenous methylglyoxal-injected rats.Heliyon · 2024Article
- Western diet-induced ultrastructural changes in mouse pancreatic acinar cells.Frontiers in cell and developmental biology · 2024Article
- Anti-Incretin Gut Features Induced by Feed Supplementation with Alpha-Amylase: Studies on EPI Pigs.International journal of molecular sciences · 2023Article
- Hypothesis that alpha-amylase evokes regulatory mechanisms originating in the pancreas, gut and circulation, which govern glucose/insulin homeostasis.World journal of diabetes · 2023Review
- Retrospective cohort study to examine the association between serum amylase and the incidence of type 2 diabetes mellitus, Toranomon Hospital Health Management Center Study 23 (TOPICS 23).BMJ open diabetes research & care · 2023Article
- Alterations of the gut microbiota in type 2 diabetics with or without subclinical hypothyroidism.PeerJ · 2023Article
- Predicting ketosis during the transition period in Holstein Friesian cows using hematological and serum biochemical parameters on the calving date.Scientific reports · 2022Article
- Fructose and methylglyoxal-induced glycation alters structural and functional properties of salivary proteins, albumin and lysozyme.PloS one · 2022Article
- Sex Modulates Cardiovascular Effects of Icodextrin-Based Peritoneal Dialysis Solutions.Frontiers in physiology · 2022Article
- Clinical Characteristics of Concomitant Diabetic Ketoacidosis in Type 2 Diabetes Patients with Acute Pancreatitis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Low and high pancreatic amylase is associated with pancreatic cancer and chronic pancreatitis.European journal of epidemiology · 2021Article
- Very Low-Calorie Ketogenic Diet Modulates the Autonomic Nervous System Activity through Salivary Amylase in Obese Population Subjects.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the last decade, low serum amylase (hypoamylasemia) has been reported in certain common cardiometabolic conditions such as obesity, diabetes (regardless of type), and metabolic syndrome, all of which appear to have a common etiology of insufficient insulin action due to insulin resistance and/or diminished insulin secretion. Some clinical studies have shown that salivary amylase may be preferentially decreased in obese individuals, whereas others have revealed that pancreatic amylase may be preferentially decreased in diabetic subjects with insulin dependence. Despite this accumulated evidence, the clinical relevance of serum, salivary, and pancreatic amylase and the underlying mechanisms have not been fully elucidated. In recent years, copy number variations (CNVs) in the salivary amylase gene (AMY1), which range more broadly than the pancreatic amylase gene (AMY2A and AMY2B), have been shown to be well correlated with salivary and serum amylase levels. In addition, low CNV of AMY1, indicating low salivary amylase, was associated with insulin resistance, obesity, low taste perception/satiety, and postprandial hyperglycemia through impaired insulin secretion at early cephalic phase. In most populations, insulin-dependent diabetes is less prevalent (minor contribution) compared with insulin-independent diabetes, and obesity is highly prevalent compared with low body weight. Therefore, obesity as a condition that elicits cardiometabolic diseases relating to insulin resistance (major contribution) may be a common determinant for low serum amylase in a general population. In this review, the novel interpretation of low serum, salivary, and pancreas amylase is discussed in terms of major contributions of obesity, diabetes, and metabolic syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.