Evidence map›Paper›PMID 27022418›Full record

ReviewTheranostics2016

DNA Nanotechnology for Cancer Therapy.

Vinit Kumar, Stefano Palazzolo, Samer Bayda, Giuseppe Corona, Giuseppe Toffoli, Flavio Rizzolio

Abstract readReview
In one paragraph

Review in Theranostics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Review
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  19. Review
  20. A DNA-based nanocarrier for efficient cancer therapy.Journal of pharmaceutical analysis · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vinit Kumar1. Experimental and Clinical Pharmacology, Department of Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO Aviano (PN), Via Franco Gallini, 2, Aviano 33081 - PN - Italy;
Stefano Palazzolo1. Experimental and Clinical Pharmacology, Department of Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO Aviano (PN), Via Franco Gallini, 2, Aviano 33081 - PN - Italy;; 2. Doctoral School in Nanotechnology, University of Trieste, Italy.
Samer Bayda1. Experimental and Clinical Pharmacology, Department of Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO Aviano (PN), Via Franco Gallini, 2, Aviano 33081 - PN - Italy;; 2. Doctoral School in Nanotechnology, University of Trieste, Italy.
Giuseppe Corona1. Experimental and Clinical Pharmacology, Department of Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO Aviano (PN), Via Franco Gallini, 2, Aviano 33081 - PN - Italy;
Giuseppe Toffoli1. Experimental and Clinical Pharmacology, Department of Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO Aviano (PN), Via Franco Gallini, 2, Aviano 33081 - PN - Italy;
Flavio Rizzolio1. Experimental and Clinical Pharmacology, Department of Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO Aviano (PN), Via Franco Gallini, 2, Aviano 33081 - PN - Italy;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA nanotechnology is an emerging and exciting field, and represents a forefront frontier for the biomedical field. The specificity of the interactions between complementary base pairs makes DNA an incredible building material for programmable and very versatile two- and three-dimensional nanostructures called DNA origami. Here, we analyze the DNA origami and DNA-based nanostructures as a drug delivery system. Besides their physical-chemical nature, we dissect the critical factors such as stability, loading capability, release and immunocompatibility, which mainly limit in vivo applications. Special attention was dedicated to highlighting the boundaries to be overcome to bring DNA nanostructures closer to the bedside of patients.

Indexed as

DNADrug CarriersDrug LiberationDrug StabilityHumansNanomedicineNanostructuresNeoplasmsDNADrug CarriersCancerDNADoxorubicinDrug deliveryNanomedicineNanotechnologyOrigami.Self-assembly

Identifiers

PMID27022418
PMCPMC4805665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.