Evidence map›Paper›PMID 27022416›Full record

ArticleTheranostics2016

A Phosphorus Phthalocyanine Formulation with Intense Absorbance at 1000 nm for Deep Optical Imaging.

Yang Zhou, Depeng Wang, Yumiao Zhang, Upendra Chitgupi, Jumin Geng, Yuehang Wang, Yuzhen Zhang, Timothy R Cook, Jun Xia, Jonathan F Lovell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 176 citations in OpenAlex.

  1. Pooled it
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  7. Bornite (CuPhotoacoustics · 2024
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yang Zhou1. College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P.R. China.; 2. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
Depeng Wang2. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
Yumiao Zhang2. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.; 3. Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
Upendra Chitgupi2. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
Jumin Geng2. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
Yuehang Wang2. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
Yuzhen Zhang4. Department of Chemistry, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
Timothy R Cook4. Department of Chemistry, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
Jun Xia2. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
Jonathan F Lovell2. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.; 3. Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
University at Buffalo, State University of New York · USMinistry of Education · ME

Funding

Light-Triggered Drug Release in Primed Pancreatic TumorsR01EB017270 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2021
$3.5M
Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR LightDP5OD017898 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2017
$1.9M
Potentiometric photoacoustic imaging of brain activity enabled by near infrared to visible light converting nanoparticlesR21EY026411 · NEI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PRASAD, PARAS N., XIA, JUN · 2015 to 2016
$447k
NEI NIH HHS R21 EY026411NEI NIH HHS R21EY026411NIBIB NIH HHS R01 EB017270NIBIB NIH HHS R01EB017270NIH HHS DP5 OD017898NIH HHS DP5OD017898
6 · The paper itself

Abstract

Although photoacoustic computed tomography (PACT) operates with high spatial resolution in biological tissues deeper than other optical modalities, light scattering is a limiting factor. The use of longer near infrared wavelengths reduces scattering. Recently, the rational design of a stable phosphorus phthalocyanine (P-Pc) with a long wavelength absorption band beyond 1000 nm has been reported. Here, we show that when dissolved in liquid surfactants, P-Pc can give rise to formulations with absorbance of greater than 1000 (calculated for a 1 cm path length) at wavelengths beyond 1000 nm. Using the broadly accessible Nd:YAG pulse laser emission output of 1064 nm, P-Pc could be imaged through 11.6 cm of chicken breast with PACT. P-Pc accumulated passively in tumors following intravenous injection in mice as observed by PACT. Following oral administration, P-Pc passed through the intestine harmlessly, and PACT could be used to non-invasively observe intestine function. When the contrast agent placed under the arm of a healthy adult human, a PACT transducer on the top of the arm could readily detect P-Pc through the entire 5 cm limb. Thus, the approach of using contrast media with extreme absorption at 1064 nm readily enables high quality optical imaging in vitro and in vivo in humans at exceptional depths.

Indexed as

Administration, IntravenousAdministration, OralAnimalsChemical PhenomenaChickensHumansIndolesIsoindolesMiceOptical ImagingPhosphorusPhotoacoustic TechniquesRadiation-Sensitizing AgentsIndolesIsoindolesPhosphorusphthalocyanineRadiation-Sensitizing Agentsphotoacoustic computed tomography

Identifiers

PMID27022416
PMCPMC4805663
OpenAlexW2315136095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.