Evidence map›Paper›PMID 27022263›Full record

ArticleInternational journal of nanomedicine2016

Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release.

Saba Atefyekta, Batur Ercan, Johan Karlsson, Erik Taylor, Stanley Chung, Thomas J Webster, Martin Andersson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. A Photocatalytic TiOMaterials (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saba AtefyektaDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Batur ErcanDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA; Department of Metallurgical and Materials Engineering, Middle East Technical University, Ankara, Turkey.
Johan KarlssonDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Erik TaylorDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.
Stanley ChungDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.
Thomas J WebsterDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden; Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Martin AnderssonDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant-associated infections are undesirable complications that might arise after implant surgery. If the infection is not prevented, it can lead to tremendous cost, trauma, and even life threatening conditions for the patient. Development of an implant coating loaded with antimicrobial substances would be an effective way to improve the success rate of implants. In this study, the in vitro efficacy of mesoporous titania thin films used as a novel antimicrobial release coating was evaluated. Mesoporous titania thin films with pore diameters of 4, 6, and 7 nm were synthesized using the evaporation-induced self-assembly method. The films were characterized and loaded with antimicrobial agents, including vancomycin, gentamicin, and daptomycin. Staphylococcus aureus and Pseudomonas aeruginosa were used to evaluate their effectiveness toward inhibiting bacterial colonization. Drug loading and delivery were studied using a quartz crystal microbalance with dissipation monitoring, which showed successful loading and release of the antibiotics from the surfaces. Results from counting bacterial colony-forming units showed reduced bacterial adhesion on the drug-loaded films. Interestingly, the presence of the pores alone had a desired effect on bacterial colonization, which can be attributed to the documented nanotopographical effect. In summary, this study provides significant promise for the use of mesoporous titania thin films for reducing implant infections.

Indexed as

Drug LiberationHydrophobic and Hydrophilic InteractionsAnti-Bacterial AgentsBacterial AdhesionDrug CarriersPorosityProstheses and ImplantsPseudomonas aeruginosaStaphylococcus aureusTitaniumAnti-Bacterial AgentsDrug CarriersTitaniumtitanium dioxideantibacterialdrug deliveryimplant coatingmesoporous titania

Identifiers

PMID27022263
PMCPMC4790524

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.