ArticleDrug design, development and therapy2016
Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis.
Article in Drug design, development and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04490967 (Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: Split Face Study
Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- The Active Shelf: A Clinician's Guide to Active Dermatologic Care for Atopic Dermatitis.The Journal of clinical and aesthetic dermatology · 2026Article
- Formulation and Characterization of Hydrogel Chitosan-Pectin Active Films Containing Silymarin.Molecules (Basel, Switzerland) · 2026Article
- Optimizing a Natural Oil-Based Sertaconazole Nitrate Organogel: enhanced antifungal activity throughJournal of pharmacopuncture · 2025Article
- Quality by design optimization of formulation variables and process parameters for enhanced transdermal delivery of nanosuspension.Drug delivery and translational research · 2025Article
- Stability and Rheological Properties of the Novel Silica-Based Organogel-A Drug Carrier with High Solubilization Potential.Materials (Basel, Switzerland) · 2025Article
- Flavonoids in atopic dermatitis: mechanisms, delivery innovations, and translational strategies.Frontiers in pharmacology · 2025Review
- Relieving postherpetic neuralgia pain via gabapentin-loaded bigels as an auspicious topical drug delivery system.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Nitric Oxide-Releasing Topical Treatments for Cutaneous Melanoma.Molecular pharmaceutics · 2024Article
- Review
- Mucoadhesive Polymeric Polyologels Designed for the Treatment of Periodontal and Related Diseases of the Oral Cavity.Polymers · 2024Article
- Silymarin and Inflammation: Food for Thoughts.Antioxidants (Basel, Switzerland) · 2024Review
- Hypothesizing the Oleic Acid-Mediated Enhanced and Sustained Transdermal Codelivery of Pregabalin and Diclofenac Adhesive Nanogel: A Proof of Concept.Current molecular medicine · 2024Article
- Poloxamer-based nanogels as delivery systems: how structural requirements can drive their biological performance?Biophysical reviews · 2023Review
- Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles.Pharmaceutics · 2023Review
- Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis.Pharmaceutics · 2023Review
- Monoketonic Curcuminoid-Lidocaine Co-Deliver Using Thermosensitive Organogels: From Drug Synthesis to Epidermis Structural Studies.Pharmaceutics · 2022Article
- Assessment of the Anti-Inflammatory, Antibacterial and Anti-Aging Properties and Possible Use on the Skin of Hydrogels ContainingFrontiers in pharmacology · 2022Article
- Neuroprotective effect of silymarin against 3-Nitropropionic acid-induced neurotoxicity in rats.Current research in pharmacology and drug discovery · 2022Article
- The Influence of Tea Tree Oil on Antifungal Activity and Pharmaceutical Characteristics of PluronicInternational journal of molecular sciences · 2021Article
- A novel quercetin/β-cyclodextrin transdermal gel, combined or not with therapeutic ultrasound, reduces oxidative stress after skeletal muscle injury.RSC advances · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silymarin is a naturally occurring flavonoid drug; evidence from recent research has highlighted its use as a potential treatment for atopic dermatitis (AD). Both poor water solubility and drug permeability have hindered the percutaneous absorption of silymarin. Formulation of silymarin into pluronic-lecithin organogel (PLO) basis for topical skin delivery is the main aim of this work. Six different PLO formulations were prepared containing various pluronic to lecithin ratios using two cosolvent systems of ethyl alcohol and dimethyl sulfoxide. Formulation 2 (20% pluronic and 3% lecithin) was found to be the optimal base for topical delivery of silymarin as it showed optimum pH, viscosity, drug content, and satisfactory in vitro silymarin permeation. The silymarin PLO formulation significantly relieved inflammatory symptoms of AD such as redness, swelling, and inflammation. These findings warrant the ability for application of these novel silymarin PLO formulations as a novel treatment for AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.