Evidence map›Paper›PMID 27022088›Full record

ArticleThe Journal of cell biology2016

Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis.

Ju Youn Kim, Samie R Jaffrey

Abstract readComment
In one paragraph

Article in The Journal of cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ju Youn KimDepartment of Pharmacology, Weill Medical College, Cornell University, New York, NY 10065.
Samie R JaffreyDepartment of Pharmacology, Weill Medical College, Cornell University, New York, NY 10065 srj2003@med.cornell.edu.

Funding

Uncovering polyadenylation pathways in neuronal signalingR01NS056306 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JAFFREY, SAMIE R · 2007 to 2018
$4.2M
NINDS NIH HHS NS056306NINDS NIH HHS R01 NS056306
6 · The paper itself

Abstract

Presynaptic differentiation is a critical and poorly understood step in synapse formation. Using compartmentalized culture systems that isolate axons and nascent synapses, Pinto et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201509039) show that the axonal ubiquitin-proteasome system locally regulates the accumulation of ubiquitinated substrates, triggering presynaptic differentiation.

Indexed as

Cell DifferentiationAnimalsHippocampusPolyubiquitinPresynaptic TerminalsProteasome Endopeptidase ComplexUbiquitinated ProteinsPolyubiquitinProteasome Endopeptidase ComplexUbiquitinated Proteins

Identifiers

PMID27022088
PMCPMC4810311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.