ArticleMolecular psychiatry2017
Transgenerational transmission and modification of pathological traits induced by prenatal immune activation.
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Maternal immune activation disrupts epigenomic and functional maturation of cortical excitatory neurons.Molecular psychiatry · 2026Article
- Grandmother's pregnancy complications and autism spectrum disorders in grandchildren, a California multigenerational cohort study.JCPP advances · 2026Article
- Astroglial disinhibition of cortical circuits disrupts cognition via kynurenic acid in mice.Nature communications · 2026Article
- From neuroinflammation to neural inference: computational psychiatry meets precision medicine.Schizophrenia (Heidelberg, Germany) · 2026Review
- Maternal immune activation with high molecular weight poly (I:C) induces selective depressive-like phenotype in adult offspring.Translational psychiatry · 2026Article
- A new two-hit animal model for schizophrenia research: Consequences on social behavior.IBRO neuroscience reports · 2025Article
- Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner.Nature communications · 2025Article
- Leveraging multigenerational health data to enhance mental disorder risk prediction: a population-based cohort study.BMC psychiatry · 2025Article
- Effects of the Prenatal Maternal Health Status on Calf Disease Prevalences and Respective Genetic Parameter Estimates in German Holstein Cattle.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Maternal Immune Activation Disrupts Epigenomic and Functional Maturation of Cortical Excitatory Neurons.bioRxiv : the preprint server for biology · 2025Article
- Improving the odds of survival: transgenerational effects of infections.EMBO molecular medicine · 2025Review
- Inter- and Transgenerational Effects of In Ovo Stimulation with Bioactive Compounds on Cecal Tonsils and Cecal Mucosa Transcriptomes in a Chicken Model.International journal of molecular sciences · 2025Article
- Differential effects of purified low molecular weight Poly(I:C) in the maternal immune activation model depend on the laboratory environment.Translational psychiatry · 2024Article
- Prenatal immune activation in mice induces long-term alterations in brain mitochondrial function.Translational psychiatry · 2024Article
- Role of the prefrontal cortical protease TACE/ADAM17 in neurobehavioral responses to chronic stress during adolescence.Brain and behavior · 2024Article
- The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders.Life (Basel, Switzerland) · 2024Review
- Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior.Molecular psychiatry · 2024Article
- Prenatal and postnatal influences on behavioral development in a mouse model of preconceptional stress.Neurobiology of stress · 2024Article
- Transcriptomic profiling of the developing brain revealed cell-type and brain-region specificity in a mouse model of prenatal stress.BMC genomics · 2023Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal exposure to infectious or inflammatory insults is increasingly recognized to contribute to the etiology of psychiatric disorders with neurodevelopmental components, including schizophrenia, autism and bipolar disorder. It remains unknown, however, if such immune-mediated brain anomalies can be transmitted to subsequent generations. Using an established mouse model of prenatal immune activation by the viral mimetic poly(I:C), we show that reduced sociability and increased cued fear expression are similarly present in the first- and second-generation offspring of immune-challenged ancestors. We further demonstrate that sensorimotor gating impairments are confined to the direct descendants of infected mothers, whereas increased behavioral despair emerges as a novel phenotype in the second generation. These transgenerational effects are mediated via the paternal lineage and are stable until the third generation, demonstrating transgenerational non-genetic inheritance of pathological traits following in-utero immune activation. Next-generation sequencing further demonstrated unique and overlapping genome-wide transcriptional changes in first- and second-generation offspring of immune-challenged ancestors. These transcriptional effects mirror the transgenerational effects on behavior, showing that prenatal immune activation leads to a transgenerational transmission (presence of similar phenotypes across generations) and modification (presence of distinct phenotypes across generations) of pathological traits. Together, our study demonstrates for, we believe, the first time that prenatal immune activation can negatively affect brain and behavioral functions in multiple generations. These findings thus highlight a novel pathological aspect of this early-life adversity in shaping disease risk across generations.
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