ArticleMolecular psychiatry2016
Genetic overlap between type 2 diabetes and depression in Swedish and Danish twin registries.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Understanding the relationship between type 2 diabetes and depression: lessons from genetically informative study designs.Diabetic medicine : a journal of the British Diabetic Association · 2021Pooled it
- First-Degree Family History of Diabetes Is Associated With the Presence of Depressive Symptoms Independent of Lifestyle Risk Factors and Cardiometabolic Risk Factors.Journal of diabetes · 2025Article
- Article
- A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity.PLoS genetics · 2023Article
- Free, Conjugated, and Bound Phenolics in Peel and Pulp from Four Wampee Varieties: Relationship between Phenolic Composition and Bio-Activities by Multivariate Analysis.Antioxidants (Basel, Switzerland) · 2022Article
- The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966.International journal of obesity (2005) · 2022Article
- Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression.International journal of molecular sciences · 2022Article
- Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes.Diabetologia · 2022Article
- Association of polygenic score for major depression with response to lithium in patients with bipolar disorder.Molecular psychiatry · 2021Article
- Genetic comorbidity between major depression and cardio-metabolic traits, stratified by age at onset of major depression.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Article
- Association of depression and diabetes complications and mortality: a population-based cohort study.Epidemiology and psychiatric sciences · 2020Article
- Chronic physical conditions and risk for perinatal mental illness: A population-based retrospective cohort study.PLoS medicine · 2019Article
- Co-shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Review
- Depression and obesity: evidence of shared biological mechanisms.Molecular psychiatry · 2019Review
- Mental and Addictive Disorders and Medical Comorbidities.Current psychiatry reports · 2018Review
- Diabetes and depression.Yeungnam University journal of medicine · 2018Review
- Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits.Psychosomatic medicine · 2018Article
- Early Combination Therapy for Type 2 Diabetes Mellitus and Common Comorbid Mental Disorders.Focus (American Psychiatric Publishing) · 2018Article
- Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study.Scientific reports · 2017Article
- Investigating shared aetiology between type 2 diabetes and major depressive disorder in a population based cohort.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A bidirectional association between type 2 diabetes (T2DM) and depression has been consistently reported. Depression is associated with worse biomedical outcomes and increased mortality. The mechanisms underlying the association of T2DM with depression remain unclear. One possible question we can address is the extent to which the co-occurrence of diabetes and depression is due to correlated genetic and/or environmental risk factors. In this study, we performed structural equation model fitting to population-level data from the Swedish (n=68 606) and Danish (n=95 403) twin registries. The primary outcomes were clinical diagnosis of T2DM and depression using national hospital discharge registries. The phenotypic correlation between T2DM and depression is modest in both samples. In the Swedish sample, unique environmental effects explain a greater proportion of the covariance in males, whereas the association is primarily attributed to genetic effects in females. In the Danish sample, genetic effects account for the majority of the covariance in both males and females. Qualitative genetic sex differences are observed in both samples. We believe this is the first study to demonstrate significant genetic overlap between T2DM and depression.
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