SynthesisValue in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
Patient-Centered Outcomes of Medication Adherence Interventions: Systematic Review and Meta-Analysis.
Synthesis in Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Impact of Interventions on Medication Adherence in Patients With Coexisting Diabetes and Hypertension.Health expectations : an international journal of public participation in health care and health policy · 2024Pooled it
- Intervention strategies to improve adherence to treatment for selected chronic conditions in sub-Saharan Africa: a systematic review.Journal of the International AIDS Society · 2024Pooled it
- Patient education interventions for the management of inflammatory bowel disease.The Cochrane database of systematic reviews · 2023Pooled it
- Effectiveness of IT-based interventions on self-management in adult kidney transplant recipients: a systematic review.BMC medical informatics and decision making · 2021Pooled it
- Pooled it
- Valuing Meta-Health Effects for Use in Economic Evaluations to Inform Reimbursement Decisions: A Review of the Evidence.PharmacoEconomics · 2017Pooled it
- A Novel Device to Improve the Tolerability of Intranasal Corticosteroid Sprays for Allergic Rhinitis and Postoperative Chronic Rhinosinusitis: A Crossover Trial.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Trial
- The Effect of an Educational Intervention on Self-Care in Patients with Venous Leg Ulcers-A Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Matching actual treatment with patient administration-route-preference improves analgesic response among acute low back pain patients-a randomized prospective trial.Journal of orthopaedic surgery and research · 2020Trial
- Advanced therapy options, choice, access, and treatment empowerment for inflammatory bowel disease (ADVOCATE-IBD): a UK-wide semi-structured interview study exploring patient preferences around advanced therapy decisions in inflammatory bowel disease.Crohn's & colitis 360 · 2026Article
- Patient Engagement in Person-Centered Communication About Medication Adherence: Perspectives From Patients, Next of Kin, and Healthcare Professionals.Patient preference and adherence · 2026Article
- Determinants of medication adherence in patients with diabetes, hypertension, and hyperlipidemia.Hormones (Athens, Greece) · 2025Article
- Assessment of Health-Related Quality of Life and Its Associated Factors Among Cardiovascular Disease Patients at a Teaching Hospital in Northwest Ethiopia: A Cross-Sectional Study.BioMed research international · 2025Article
- Healthcare provider interventions to support medication adherence: state-of-the-science overview.Frontiers in pharmacology · 2025Review
- A Systematic Review of Controlled Trials: Can Patient Adherence to Antibiotics Be Improved Through Pharmaceutical Communication-Based Interventions?Pharmacy (Basel, Switzerland) · 2024Review
- Association Between Quality of Life and Drug Adherence Among Patients With Diabetes in India.Cureus · 2024Article
- Decision-making in the multiphase optimization strategy: Applying decision analysis for intervention value efficiency to optimize an information leaflet to promote key antecedents of medication adherence.Translational behavioral medicine · 2024Article
- Association between medication adherence and health-related quality of life of patients with hypertension and dyslipidemia.Hormones (Athens, Greece) · 2023Article
- Knowledge Assessment During the Medication Process Use by Older Patients on Clinical Routine: A Pilot Study.Turkish journal of pharmaceutical sciences · 2023Article
- Association between medication adherence and health-related quality of life of patients with diabetes.Hormones (Athens, Greece) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveUsing meta-analytic procedures to synthesize changes in patient-centered outcomes after medication adherence interventions.
methodsStrategies to locate studies included online searches of 13 databases and 19 research registries, hand searches of 57 journals, and author and ancestry searches of all eligible studies. Search terms included patient compliance, medication adherence, and related terms. Searches were conducted for all studies published since 1960. Eligible published or unpublished primary studies tested medication adherence interventions and reported medication knowledge, quality of life, physical function, and symptom outcomes. Primary study attributes and outcome data were reliably coded. Overall standardized mean differences (SMDs) were analyzed using random-effects models. Dichotomous and continuous moderator analyses and funnel plots were used to explore risks of bias.
resultsThorough searching located 141 eligible reports. The reports included 176 eligible comparisons between treatment and control subjects across 23,318 subjects. Synthesis across all comparisons yielded statistically significant SMDs for medication knowledge (d = 0.449), quality of life (d = 0.127), physical function (d = 0.142), and symptoms (d = 0.182). The overall SMDs for studies focusing on subsamples of patients with specific illnesses were more modest but also statistically significant. Of specific symptoms analyzed (depression, anxiety, pain, energy/vitality, cardiovascular, and respiratory), only anxiety failed to show a significant improvement after medication adherence interventions. Most SMDs were significantly heterogeneous, and risk of bias analyses suggested links between study quality and SMDs.
conclusionsModest but significant improvements in patient-centered outcomes were observed after medication adherence interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.