ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2016
Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.Nature communications · 2021Pooled it
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- Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement.Diseases (Basel, Switzerland) · 2024Article
- Heritability and genetic contribution analysis of structural-functional coupling in human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
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- Common protein-coding variants influence the racing phenotype in galloping racehorse breeds.Communications biology · 2022Article
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- Recursive splicing is a rare event in the mouse brain.PloS one · 2022Article
- Deep learning model reveals potential risk genes for ADHD, especially Ephrin receptor gene EPHA5.Briefings in bioinformatics · 2021Article
- On the functional relevance of spatiotemporally-specific patterns of experience-dependent long noncoding RNA expression in the brain.RNA biology · 2021Review
- Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene.Translational psychiatry · 2021Article
- The Co-existence of ADHD With Autism in Saudi Children: An Analysis Using Next-Generation DNA Sequencing.Frontiers in genetics · 2020Article
- An integrated analysis of genes and functional pathways for aggression in human and rodent models.Molecular psychiatry · 2019Article
- A Proteomic Screen of Neuronal Cell-Surface Molecules Reveals IgLONs as Structurally Conserved Interaction Modules at the Synapse.Structure (London, England : 1993) · 2019Article
- Moderating effect of mode of delivery on the genetics of intelligence: Explorative genome-wide analyses in ALSPAC.Brain and behavior · 2018Article
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- Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation.Frontiers in molecular neuroscience · 2017Review
- Molecular genetic approaches to understanding the comorbidity of psychiatric disorders.Development and psychopathology · 2016Review
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Authors and funding
22 authors at 14 institutions in 6 countries.
Funding
Abstract
Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome-wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome-wide significance (P < 5.00E-08). The strongest signal in aADHD was observed at rs10826548, within a long noncoding RNA gene (beta = -1.66, standard error (SE) = 0.34, P = 1.07E-06), closely followed by rs35974940 in the neurotrimin gene (beta = 3.23, SE = 0.67, P = 1.26E-06). The top GWA SNPs observed in aADHD showed significant enrichment of signals from both the defiant/vindictive dimension (Fisher's P-value = 2.28E-06) and the irritable dimension in cADHD (Fisher's P-value = 0.0061). In sum, our results identify a number of biologically interesting markers possibly underlying childhood aggressiveness and provide targets for further genetic exploration of aggressiveness across psychiatric disorders. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.
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