ArticleScientific reports2016
A Controlled Design of Aligned and Random Nanofibers for 3D Bi-functionalized Nerve Conduits Fabricated via a Novel Electrospinning Set-up.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Biocompatibility and antibacterial properties of ordered PLA fiber membranes fabricated via electrospinning technology.iScience · 2026Article
- Investigating the Cellular Activity and Differential Gene Expression of Human Astrocytes in Interaction with Protein Composite Nanofibers.Neurochemical research · 2026Article
- Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber drawing method: A rabbit model study.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- The functional regulation of protein composite nanofibers on human astrocyte for neural regeneration.Research square · 2025Article
- Peripheral nerve regeneration using a bioresorbable silk fibroin-based artificial nerve conduit fabricated via a novel freeze-thaw process.Scientific reports · 2025Article
- Electrospinning based biomaterials for biomimetic fabrication, bioactive protein delivery and wound regenerative repair.Regenerative biomaterials · 2025Review
- Evaluating the efficacy of uniformly designed square mesh resin 3D printed scaffolds in directing the orientation of electrospun PCL nanofibers.Scientific reports · 2024Article
- Recent advances in enhances peripheral nerve orientation: the synergy of micro or nano patterns with therapeutic tactics.Journal of nanobiotechnology · 2024Review
- Adsorptive removal of organophosphate pesticides from aqueous solution using electrospun carbon nanofibers.Frontiers in chemistry · 2024Article
- Fabricating orientated nanofibrous meshes with a bespoke ultra-cost-effective electrospinning machine.HardwareX · 2023Article
- Fibrin gel enhanced trilayer structure in cell-cultured constructs.Biotechnology and bioengineering · 2023Article
- An origami-based technique for simple, effective and inexpensive fabrication of highly aligned far-field electrospun fibers.Scientific reports · 2023Article
- Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress.Pharmaceutics · 2023Review
- Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury.RSC advances · 2023Article
- Biomimetic Strategies for Peripheral Nerve Injury Repair: An Exploration of Microarchitecture and Cellularization.Biomedical materials & devices (New York, N.Y.) · 2023Article
- Electroceuticals for peripheral nerve regeneration.Biofabrication · 2022Review
- Article
- Biobased Elastomer Nanofibers Guide Light-Controlled Human-iPSC-Derived Skeletal Myofibers.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Growth of MIN-6 Cells on Salmon Fibrinogen Scaffold Improves Insulin Secretion.Pharmaceutics · 2022Article
- Optimal Morphometric Characteristics of a Tubular Polymeric Scaffold to Promote Peripheral Nerve Regeneration: A Scoping Review.Polymers · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scaffolds made of aligned nanofibers are favorable for nerve regeneration due to their superior nerve cell attachment and proliferation. However, it is challenging not only to produce a neat mat or a conduit form with aligned nanofibers but also to use these for surgical applications as a nerve guide conduit due to their insufficient mechanical strength. Furthermore, no studies have been reported on the fabrication of aligned nanofibers and randomly-oriented nanofibers on the same mat. In this study, we have successfully produced a mat with both aligned and randomly-oriented nanofibers by using a novel electrospinning set up. A new conduit with a highly-aligned electrospun mat is produced with this modified electrospinning method, and this proposed conduit with favorable features, such as selective permeability, hydrophilicity and nerve growth directional steering, were fabricated as nerve guide conduits (NGCs). The inner surface of the nerve conduit is covered with highly aligned electrospun nanofibers and is able to enhance the proliferation of neural cells. The central part of the tube is double-coated with randomly-oriented nanofibers over the aligned nanofibers, strengthening the weak mechanical strength of the aligned nanofibers.
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Registered trials
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