ArticleJournal of radiation research2016
Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice.
Article in Journal of radiation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy.Journal of clinical biochemistry and nutrition · 2022Article
- Using Collagen Peptides From the Skin of Monkfish (Frontiers in nutrition · 2022Article
- Inosine induces acute hyperuricaemia in rhesus monkey (Pharmaceutical biology · 2021Article
- Radon Exposure-Therapeutic Effect and Cancer Risk.International journal of molecular sciences · 2020Review
- Lifeceramics-treated water reduces serum uric acid levels and improves hemorheological activity in hyperuricemic rats.Biomedical reports · 2020Article
- Protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice.Journal of radiation research · 2017Article
- Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis).Experimental animals · 2017Article
- Present and Future Prospects of Radiation Therapy Using α-Emitting Nuclides.Dose-response : a publication of International Hormesis SocietyArticle
- Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although radon therapy is indicated for hyperuricemia, the underlying mechanisms of action have not yet been elucidated in detail. Therefore, we herein examined the inhibitory effects of radon inhalation and hot spring water drinking on potassium oxonate (PO)-induced hyperuricemia in mice. Mice inhaled radon at a concentration of 2000 Bq/m(3) for 24 h or were given hot spring water for 2 weeks. Mice were then administrated PO at a dose of 500 mg/kg. The results obtained showed that serum uric acid levels were significantly increased by the administration of PO. Radon inhalation or hot spring water drinking significantly inhibited elevations in serum uric acid levels through the suppression of xanthine oxidase activity in the liver. Radon inhalation activated anti-oxidative functions in the liver and kidney. These results suggest that radon inhalation inhibits PO-induced hyperuricemia by activating anti-oxidative functions, while hot spring water drinking may suppress PO-induced elevations in serum uric acid levels through the pharmacological effects of the chemical compositions dissolved in it.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.