Evidence map›Paper›PMID 27021188›Full record

ArticlePlant physiology2016

A Formate Dehydrogenase Confers Tolerance to Aluminum and Low pH.

He Qiang Lou, Yu Long Gong, Wei Fan, Jia Meng Xu, Yu Liu, Meng Jie Cao, Ming-Hu Wang, Jian Li Yang, Shao Jian Zheng

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
12.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
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  18. Review
  19. Aluminum Responsive Genes in Flax (BioMed research international · 2019
    Article
  20. Stress response of NADEnvironmental science and pollution research international · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

He Qiang LouState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China (H.Q.L., Y.L.G., J.M.X., Y.L., M.J.C., J.L.Y., S.J.Z.); College of Resources and Environment, Yunnan Agricultural University, Kunming 650201, China (W.F.); and Ningbo Municipal Head Station for Crop Farming Administration, Ningbo 315012, China (M.-H.W.).ORCID 0000-0002-2454-098X
Yu Long GongState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China (H.Q.L., Y.L.G., J.M.X., Y.L., M.J.C., J.L.Y., S.J.Z.); College of Resources and Environment, Yunnan Agricultural University, Kunming 650201, China (W.F.); and Ningbo Municipal Head Station for Crop Farming Administration, Ningbo 315012, China (M.-H.W.).
Wei FanState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China (H.Q.L., Y.L.G., J.M.X., Y.L., M.J.C., J.L.Y., S.J.Z.); College of Resources and Environment, Yunnan Agricultural University, Kunming 650201, China (W.F.); and Ningbo Municipal Head Station for Crop Farming Administration, Ningbo 315012, China (M.-H.W.).
Jia Meng XuState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China (H.Q.L., Y.L.G., J.M.X., Y.L., M.J.C., J.L.Y., S.J.Z.); College of Resources and Environment, Yunnan Agricultural University, Kunming 650201, China (W.F.); and Ningbo Municipal Head Station for Crop Farming Administration, Ningbo 315012, China (M.-H.W.).
Yu LiuState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China (H.Q.L., Y.L.G., J.M.X., Y.L., M.J.C., J.L.Y., S.J.Z.); College of Resources and Environment, Yunnan Agricultural University, Kunming 650201, China (W.F.); and Ningbo Municipal Head Station for Crop Farming Administration, Ningbo 315012, China (M.-H.W.).
Meng Jie CaoState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China (H.Q.L., Y.L.G., J.M.X., Y.L., M.J.C., J.L.Y., S.J.Z.); College of Resources and Environment, Yunnan Agricultural University, Kunming 650201, China (W.F.); and Ningbo Municipal Head Station for Crop Farming Administration, Ningbo 315012, China (M.-H.W.).
Ming-Hu WangState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China (H.Q.L., Y.L.G., J.M.X., Y.L., M.J.C., J.L.Y., S.J.Z.); College of Resources and Environment, Yunnan Agricultural University, Kunming 650201, China (W.F.); and Ningbo Municipal Head Station for Crop Farming Administration, Ningbo 315012, China (M.-H.W.).
Jian Li YangState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China (H.Q.L., Y.L.G., J.M.X., Y.L., M.J.C., J.L.Y., S.J.Z.); College of Resources and Environment, Yunnan Agricultural University, Kunming 650201, China (W.F.); and Ningbo Municipal Head Station for Crop Farming Administration, Ningbo 315012, China (M.-H.W.) yangjianli@zju.edu.cn.ORCID 0000-0003-0385-5787
Shao Jian ZhengState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China (H.Q.L., Y.L.G., J.M.X., Y.L., M.J.C., J.L.Y., S.J.Z.); College of Resources and Environment, Yunnan Agricultural University, Kunming 650201, China (W.F.); and Ningbo Municipal Head Station for Crop Farming Administration, Ningbo 315012, China (M.-H.W.).ORCID 0000-0002-3336-8165
Yunnan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Formate dehydrogenase (FDH) is involved in various higher plant abiotic stress responses. Here, we investigated the role of rice bean (Vigna umbellata) VuFDH in Al and low pH (H(+)) tolerance. Screening of various potential substrates for the VuFDH protein demonstrated that it functions as a formate dehydrogenase. Quantitative reverse transcription-PCR and histochemical analysis showed that the expression of VuFDH is induced in rice bean root tips by Al or H(+) stresses. Fluorescence microscopic observation of VuFDH-GFP in transgenic Arabidopsis plants indicated that VuFDH is localized in the mitochondria. Accumulation of formate is induced by Al and H(+) stress in rice bean root tips, and exogenous application of formate increases internal formate content that results in the inhibition of root elongation and induction of VuFDH expression, suggesting that formate accumulation is involved in both H(+)- and Al-induced root growth inhibition. Over-expression of VuFDH in tobacco (Nicotiana tabacum) results in decreased sensitivity to Al and H(+) stress due to less production of formate in the transgenic tobacco lines under Al and H(+) stresses. Moreover, NtMATE and NtALS3 expression showed no changes versus wild type in these over-expression lines, suggesting that herein known Al-resistant mechanisms are not involved. Thus, the increased Al tolerance of VuFDH over-expression lines is likely attributable to their decreased Al-induced formate production. Taken together, our findings advance understanding of higher plant Al toxicity mechanisms, and suggest a possible new route toward the improvement of plant performance in acidic soils, where Al toxicity and H(+) stress coexist.

Indexed as

AluminumArabidopsisCloning, MolecularFormate DehydrogenasesFormatesGene Expression Regulation, PlantHydrogen-Ion ConcentrationMitochondrial ProteinsNicotianaPlant ProteinsPlant RootsPlants, Genetically ModifiedVignaAluminumFormate DehydrogenasesFormatesformic acidMitochondrial ProteinsPlant Proteins

Identifiers

PMID27021188
PMCPMC4854670
OpenAlexW2345745098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.