ArticleBone2016
Microstructural and compositional contributions towards the mechanical behavior of aging human bone measured by cyclic and impact reference point indentation.
Article in Bone, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Added Value of Impact Microindentation in the Evaluation of Bone Fragility: A Systematic Review of the Literature.Frontiers in endocrinology · 2020Pooled it
- Objective selection of bone mimetic materials using impact microindentation.Journal of orthopaedics · 2026Article
- Long-duration type 1 diabetes is associated with deficient cortical bone mechanical behavior and altered matrix composition in human femoral bone.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Total body irradiation is associated with long-term deficits in femoral bone structure but not mechanical properties in male rhesus macaques.Scientific reports · 2024Article
- Cortical and trabecular mechanical properties in the femoral neck vary differently with changes in bone mineral density.JBMR plus · 2024Article
- In Vivo Assessment of Bone Quality Without X-rays.Current osteoporosis reports · 2024Review
- Assessment of bovine cortical bone fracture behavior using impact microindentation as a surrogate of fracture toughness.JBMR plus · 2024Article
- Reference Intervals for Bone Impact Microindentation in Healthy Adults: A Multi-Centre International Study.Calcified tissue international · 2023Article
- The role of microscopic properties on cortical bone strength of femoral neck.BMC musculoskeletal disorders · 2023Article
- Review
- Complications in the spine associated with type 2 diabetes: The role of advanced glycation end-products.Medicine in novel technology and devices · 2021Article
- Is the 0.2%-Strain-Offset Approach Appropriate for Calculating the Yield Stress of Cortical Bone?Annals of biomedical engineering · 2021Article
- In Vitro-Induced High Sugar Environments Deteriorate Human Cortical Bone Elastic Modulus and Fracture Toughness.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- PTH and bone material strength in hypoparathyroidism as measured by impact microindentation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Ionizing radiation and bone quality: time-dependent effects.Radiation oncology (London, England) · 2019Article
- Clinical measurements of bone tissue mechanical behavior using reference point indentation.Clinical reviews in bone and mineral metabolism · 2018Article
- Local bone quality measurements correlates with maximum screw torque at the femoral diaphysis.Clinical biomechanics (Bristol, Avon) · 2018Article
- The effect of aminoguanidine (AG) and pyridoxamine (PM) on ageing human cortical bone.Bone & joint research · 2018Article
- Differences in sensitivity to microstructure between cyclic- and impact-based microindentation of human cortical bone.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Loss of scleraxis in mice leads to geometric and structural changes in cortical bone, as well as asymmetry in fracture healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The assessment of fracture risk often relies primarily on measuring bone mineral density, thereby accounting for only a single pathology: the loss of bone mass. However, bone's ability to resist fracture is a result of its biphasic composition and hierarchical structure that imbue it with high strength and toughness. Reference point indentation (RPI) testing is designed to directly probe bone mechanical behavior at the microscale in situ, although it remains unclear which aspects of bone composition and structure influence the results at this scale. Therefore, our goal in this study was to investigate factors that contribute to bone mechanical behavior measured by cyclic reference point indentation, impact reference point indentation, and three-point bending. Twenty-eight female cadavers (ages 57-97) were subjected to cyclic and impact RPI in parallel at the unmodified tibia mid-diaphysis. After RPI, the middiaphyseal tibiae were removed, scanned using micro-CT to obtain cortical porosity (Ct.Po.) and tissue mineral density (TMD), then tested using three-point bending, and lastly assayed for the accumulation of advanced glycation end-products (AGEs). Both the indentation distance increase from cyclic RPI (IDI) and bone material strength index from impact RPI (BMSi) were significantly correlated with TMD (r=-0.390, p=0.006; r=0.430, p=0.002; respectively). Accumulation of AGEs was significantly correlated with IDI (r=0.281, p=0.046), creep indentation distance (CID, r=0.396, p=0.004), and BMSi (r=-0.613, p<0.001). There were no significant relationships between tissue TMD or AGEs accumulation with the quasi-static material properties. Toughness decreased with increasing tissue Ct.Po. (r=-0.621, p<0.001). Other three-point bending measures also correlated with tissue Ct.Po. including the bending modulus (r=-0.50, p<0.001) and ultimate stress (r=-0.56, p<0.001). The effects of Ct.Po. on indentation were less pronounced with IDI (r=0.290, p=0.043) and BMSi (r=-0.299, p=0.037) correlated modestly with tissue Ct.Po. These results suggest that RPI may be sensitive to bone quality changes relating to collagen.
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