ArticlePediatric nephrology (Berlin, Germany)1989
Treatment of severe IgA nephropathy in children.
Article in Pediatric nephrology (Berlin, Germany), 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- IPNA clinical practice recommendations for the diagnosis and management of children with IgA nephropathy and IgA vasculitis nephritis.Pediatric nephrology (Berlin, Germany) · 2025Guideline
- Effects of cyclosporin A therapy combined with steroids and angiotensin converting enzyme inhibitors on childhood IgA nephropathy.Journal of Korean medical science · 2010Trial
- Efficacy of tonsillectomy pulse therapy versus multiple-drug therapy for IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2006Trial
- Early treatment with oral immunosuppressants in severe proteinuric purpura nephritis.Pediatric nephrology (Berlin, Germany) · 2003Trial
- Differences in response to treatment in children with severe IgA nephropathy according to patient age.Fukushima journal of medical science · 2023Article
- Treatment strategy with multidrug therapy and tonsillectomy pulse therapy for childhood-onset severe IgA nephropathy.Clinical and experimental nephrology · 2022Review
- Clinicopathological significance of glomerular capillary IgA deposition in childhood IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2021Article
- Clinicopathological features and prognosis of membranoproliferative-like Henoch-Schönlein purpura nephritis in children.World journal of pediatrics : WJP · 2015Article
- Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy.Experimental and therapeutic medicine · 2014Article
- Imbalance towards Th1 pathway predominance in purpura nephritis with proteinuria.Pediatric nephrology (Berlin, Germany) · 2011Article
- Successful therapy with tonsillectomy for severe ISKDC grade VI Henoch-Schönlein purpura nephritis and persistent nephrotic syndrome.Clinical and experimental nephrology · 2011Article
- Early treatment with methylprednisolone pulse therapy combined with tonsillectomy for heavy proteinuric henoch-schönlein purpura nephritis in children.Nephron extra · 2011Article
- Idiopathic immunoglobulin A nephropathy in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2010Review
- Treatment of severe Henoch-Schönlein and immunoglobulin A nephritis. A single center experience.Pediatric nephrology (Berlin, Germany) · 2009Article
- The improvement of renal survival with steroid pulse therapy in IgA nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2008Article
- Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis.Pediatric nephrology (Berlin, Germany) · 2008Article
- Outcome of Henoch-Schönlein purpura nephritis treated with long-term immunosuppression.Pediatric nephrology (Berlin, Germany) · 2007Article
- Factors affecting histological regression of crescentic Henoch-Schönlein nephritis in children.Pediatric nephrology (Berlin, Germany) · 2006Article
- Cyclosporin A therapy for severe Henoch-Schönlein nephritis with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2005Article
- Can azathioprine and steroids alter the progression of severe Henoch-Schönlein nephritis in children?Pediatric nephrology (Berlin, Germany) · 2005Article
Corrections and comments
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2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We treated ten children with severe IgA nephropathy (IgAN) [proteinuria greater than 1 g/day, hypertension, renal insufficiency, segmental sclerosis, crescent formation and/or glomerular basement membrane (GBM) deposition of IgA] with prednisone and azathioprine for 1 year. Following the year of therapy, seven of the ten children underwent a repeat kidney biopsy. All biopsies were scored for activity (percentage of glomeruli demonstrating crescent formation, degree of mesangial proliferation and interstitial infiltrate; maximum score = 9) and chronicity (percentage of glomeruli demonstrating fibrous crescents, segmental sclerosis, global sclerosis, and degree of tubular atrophy and interstitial fibrosis; maximum score = 12). After 1 year of therapy, the protein excretion of all the children decreased significantly (P less than 0.01) from 4,052 +/- 3,190 mg/day to 1,692 +/- 1,634 mg/day. The activity score decreased significantly (P less than 0.01) from 4.35 +/- 0.94 prior to therapy to 2.28 +/- 0.75 after therapy while the chronicity score was unchanged (5.42 +/- 1.7 vs 5.85 +/- 2.0). The percentage of glomeruli demonstrating cellular crescents decreased (P less than 0.05) from 21.2 +/- 21.7% prior to therapy to 0.94 +/- 2.4% after therapy. Mesangial deposition of IgA persisted but GBM deposition of IgA was less prominent after therapy. During the follow-up period (mean 2.6 years, range 9 months-7.5 years), one child required brief retreatment for biopsy-confirmed recurrence of active disease, two children have developed renal insufficiency due to progressive scarring in the absence of inflammation, while the remaining seven are stable. We suggest that treatment with prednisone and azathioprine may be beneficial in children with severe IgAN and that a controlled clinical trial is warranted.
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