Evidence map›Paper›PMID 27021009›Full record

ArticleHypertension (Dallas, Tex. : 1979)2016

Sympathetic Neural and Hemodynamic Responses During Cold Pressor Test in Elderly Blacks and Whites.

Yoshiyuki Okada, Sara S Jarvis, Stuart A Best, Jeffrey G Edwards, Joseph M Hendrix, Beverley Adams-Huet, Wanpen Vongpatanasin, Benjamin D Levine, Qi Fu

Erratum issuedOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. CD8American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  8. Article
  9. Article
  10. Sympathetic transduction at rest and during cold pressor test in young healthy non-Hispanic Black and White women.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  11. Greater resting muscle sympathetic nerve activity reduces cold pressor autonomic reactivity in older women, but not older men.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  12. Article
  13. Sympathetic transduction in humans: recent advances and methodological considerations.American journal of physiology. Heart and circulatory physiology · 2021
    Review
  14. Article
  15. Racial disparities in cardiovascular disease risk: mechanisms of vascular dysfunction.American journal of physiology. Heart and circulatory physiology · 2019
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yoshiyuki OkadaFrom the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (Y.O., S.S.J., S.A.B., J.G.E., B.D.L., Q.F.); Departments of Internal Medicine (Y.O., S.S.J., S.A.B., B.A.-H., W.V., B.D.L., Q.F.) and Anesthesiology and Pain (J.M.H.), UT Southwestern Medical Center, Dallas, TX; Department of Special Care Dentistry, Matsumoto Dental University, Nagano, Japan (Y.O.); and Department of Biological Sciences, Northern Arizona University, Flagstaff (S.S.J.).
Sara S JarvisFrom the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (Y.O., S.S.J., S.A.B., J.G.E., B.D.L., Q.F.); Departments of Internal Medicine (Y.O., S.S.J., S.A.B., B.A.-H., W.V., B.D.L., Q.F.) and Anesthesiology and Pain (J.M.H.), UT Southwestern Medical Center, Dallas, TX; Department of Special Care Dentistry, Matsumoto Dental University, Nagano, Japan (Y.O.); and Department of Biological Sciences, Northern Arizona University, Flagstaff (S.S.J.).
Stuart A BestFrom the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (Y.O., S.S.J., S.A.B., J.G.E., B.D.L., Q.F.); Departments of Internal Medicine (Y.O., S.S.J., S.A.B., B.A.-H., W.V., B.D.L., Q.F.) and Anesthesiology and Pain (J.M.H.), UT Southwestern Medical Center, Dallas, TX; Department of Special Care Dentistry, Matsumoto Dental University, Nagano, Japan (Y.O.); and Department of Biological Sciences, Northern Arizona University, Flagstaff (S.S.J.).
Jeffrey G EdwardsFrom the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (Y.O., S.S.J., S.A.B., J.G.E., B.D.L., Q.F.); Departments of Internal Medicine (Y.O., S.S.J., S.A.B., B.A.-H., W.V., B.D.L., Q.F.) and Anesthesiology and Pain (J.M.H.), UT Southwestern Medical Center, Dallas, TX; Department of Special Care Dentistry, Matsumoto Dental University, Nagano, Japan (Y.O.); and Department of Biological Sciences, Northern Arizona University, Flagstaff (S.S.J.).
Joseph M HendrixFrom the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (Y.O., S.S.J., S.A.B., J.G.E., B.D.L., Q.F.); Departments of Internal Medicine (Y.O., S.S.J., S.A.B., B.A.-H., W.V., B.D.L., Q.F.) and Anesthesiology and Pain (J.M.H.), UT Southwestern Medical Center, Dallas, TX; Department of Special Care Dentistry, Matsumoto Dental University, Nagano, Japan (Y.O.); and Department of Biological Sciences, Northern Arizona University, Flagstaff (S.S.J.).
Beverley Adams-HuetFrom the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (Y.O., S.S.J., S.A.B., J.G.E., B.D.L., Q.F.); Departments of Internal Medicine (Y.O., S.S.J., S.A.B., B.A.-H., W.V., B.D.L., Q.F.) and Anesthesiology and Pain (J.M.H.), UT Southwestern Medical Center, Dallas, TX; Department of Special Care Dentistry, Matsumoto Dental University, Nagano, Japan (Y.O.); and Department of Biological Sciences, Northern Arizona University, Flagstaff (S.S.J.).
Wanpen VongpatanasinFrom the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (Y.O., S.S.J., S.A.B., J.G.E., B.D.L., Q.F.); Departments of Internal Medicine (Y.O., S.S.J., S.A.B., B.A.-H., W.V., B.D.L., Q.F.) and Anesthesiology and Pain (J.M.H.), UT Southwestern Medical Center, Dallas, TX; Department of Special Care Dentistry, Matsumoto Dental University, Nagano, Japan (Y.O.); and Department of Biological Sciences, Northern Arizona University, Flagstaff (S.S.J.).
Benjamin D LevineFrom the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (Y.O., S.S.J., S.A.B., J.G.E., B.D.L., Q.F.); Departments of Internal Medicine (Y.O., S.S.J., S.A.B., B.A.-H., W.V., B.D.L., Q.F.) and Anesthesiology and Pain (J.M.H.), UT Southwestern Medical Center, Dallas, TX; Department of Special Care Dentistry, Matsumoto Dental University, Nagano, Japan (Y.O.); and Department of Biological Sciences, Northern Arizona University, Flagstaff (S.S.J.).
Qi FuFrom the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (Y.O., S.S.J., S.A.B., J.G.E., B.D.L., Q.F.); Departments of Internal Medicine (Y.O., S.S.J., S.A.B., B.A.-H., W.V., B.D.L., Q.F.) and Anesthesiology and Pain (J.M.H.), UT Southwestern Medical Center, Dallas, TX; Department of Special Care Dentistry, Matsumoto Dental University, Nagano, Japan (Y.O.); and Department of Biological Sciences, Northern Arizona University, Flagstaff (S.S.J.). QiFu@TexasHealth.org.
Matsumoto Dental University · JPNorthern Arizona University · USPresbyterian Hospital · USTexas Health Dallas · US

Funding

Hypertension and Antihypertensive Therapy in Elderly WomenR01HL091078 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI FU, QI · 2008 to 2011
$1.6M
NHLBI NIH HHS R01 HL091078NHLBI NIH HHS R01HL091078
6 · The paper itself

Abstract

The sympathetic response during the cold pressor test (CPT) has been reported to be greater in young blacks than whites, especially in those with a family history of hypertension. Because blood pressure (BP) increases with age, we evaluated whether elderly blacks have greater sympathetic activation during CPT than age-matched whites. BP, heart rate, cardiac output, and muscle sympathetic nerve activity were measured during supine baseline, 2-minute CPT, and 3-minute recovery in 47 elderly (68 ± 7 [SD] years) volunteers (12 blacks and 35 whites). Baseline BP, heart rate, cardiac output, or muscle sympathetic nerve activity did not differ between races. Systolic and diastolic BP and heart rate increased during CPT (all P<0.001) with no racial differences (all P > 0.05). Cardiac output increased during CPT and ≤ 30 s of recovery in both groups, but was lower in blacks than whites. Muscle sympathetic nerve activity increased during CPT in both groups (both P<0.001); the increase in burst frequency was similar between groups, whereas the increase in total activity was smaller in blacks (P=0.030 for interaction). Peak change (Δ) in diastolic BP was correlated with Δ total activity at 1 minute into CPT in both blacks (r=0.78,P=0.003) and whites (r=0.43,P=0.009), whereas the slope was significantly greater in blacks (P=0.007). Thus, elderly blacks have smaller sympathetic and central hemodynamic (eg, cardiac output) responses, but a greater pressor response for a given sympathetic activation during CPT than elderly whites. This response may stem from augmented sympathetic vascular transduction, greater sympathetic activation to other vascular bed(s), or enhanced nonadrenergically mediated vasoconstriction in elderly blacks.

Indexed as

Cold TemperatureAgedAged, 80 and overAgingAnalysis of VarianceBlack PeopleBlood Pressure DeterminationCardiac OutputChi-Square DistributionCohort StudiesDiagnostic Tests, RoutineElectrocardiographyFemaleHeart RateHemodynamicsHumansagingblood pressurecardiac outputheart ratehypertension

Identifiers

PMID27021009
PMCPMC4833636
OpenAlexW2322296313

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.