Evidence map›Paper›PMID 27020912›Full record

Trial reportClinical oral investigations2017

In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion.

Andressa Feitosa Bezerra de Oliveira, Luciana Vilar de Oliveira Diniz, Franklin Delano Soares Forte, Fabio Correia Sampaio, Renzo Alberto Ccahuana-Vásquez, Bennett Tochukwu Amaechi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. In situ effect of CPP-ACP chewing gum upon erosive enamel loss.Journal of applied oral science : revista FOB
    Trial
  4. Article
  5. Article
  6. Enamel erosion control by strontium-containing TiOClinical oral investigations · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andressa Feitosa Bezerra de OliveiraHealth Science Center, Federal University of Paraíba, Campus I - Cidade Universitária, s/n Castelo Branco, Joâo Pessoa, Paraíba, 58.051-900, Brazil. andressafeitosa@msn.com.
Luciana Vilar de Oliveira DinizUniversity Centre of João Pessoa (UNIPÊ), Rodovia BR 230 - Km 22, s/n, Água Fria, João Pessoa, Paraíba, 58053-000, Brazil.
Franklin Delano Soares ForteHealth Science Center, Federal University of Paraíba, Campus I - Cidade Universitária, s/n Castelo Branco, Joâo Pessoa, Paraíba, 58.051-900, Brazil.
Fabio Correia SampaioHealth Science Center, Federal University of Paraíba, Campus I - Cidade Universitária, s/n Castelo Branco, Joâo Pessoa, Paraíba, 58.051-900, Brazil.
Renzo Alberto Ccahuana-VásquezBraun GmbH, German Innovation Center Campus Kronberg, Frankfurter Strasse, 145 61476, Kronberg, Germany.
Bennett Tochukwu AmaechiUniversity of Texas Health Science Center, San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe purpose of this study is to analyze the in situ effect of a casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) chewing gum on human enamel erosion lesion associated or not with abrasion. MATERIAL AND

methodsA three-way crossover study of 7 days was conducted involving 10 volunteers subjected to the same protocol: (G1) CPP-ACP sugar-free chewing gum, (G2) regular sugar-free chewing gum without CPP-ACP, and (G3) saliva-no chewing gum. An abrasion test was included in each phase. A 3D non-contact profilometry measurement of lesion depth and surface roughness was obtained of sound and eroded surfaces. A salivary calcium concentration was determined for all volunteers. ANOVA followed by Tukey's test were used with a p < 0.05.

resultsThe enamel depth and the enamel surface roughness of the CPP-ACP gum group were significantly lower than the others (ANOVA, p < 0.05). No significant differences were observed between the treatments when associated with abrasion (p > 0.05). A positive and significant correlation was seen between the lesion depth and enamel surface roughness for GI (r = 0.87, p = 0.00) and GIII (r = 0.79, p = 0.00) groups. The estimated total calcium presented in the saliva after the chewed CPP-ACP gum showed no statistical significance between the mean absorbance values at the different time collections (p > 0.05).

conclusionsIt is demonstrated that the incorporation of the CPP-ACP into a sugar-free gum significantly increased the remineralization/protection of eroded enamel surface. CLINICAL RELEVANCE: The CPP-ACP added to gum may be a suitable alternative vehicle, to deliver calcium ions to saliva and therefore protecting enamel.

Indexed as

Chewing GumAdultCaseinsCross-Over StudiesDouble-Blind MethodFemaleHumansMaleSurface PropertiesTooth AbrasionTooth ErosionTreatment Outcomecasein phosphopeptide-amorphous calcium phosphate nanocomplexCaseinsChewing GumCalcium phosphateCasein phosphopeptide-amorphousEnamelErosion

Identifiers

PMID27020912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.