Evidence map›Paper›PMID 27020854›Full record

ArticleJournal of the American Society of Nephrology : JASN2016

Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells.

Wilna Oosthuyzen, Kathleen M Scullion, Jessica R Ivy, Emma E Morrison, Robert W Hunter, Philip J Starkey Lewis, Eoghan O'Duibhir, Jonathan M Street, Andrea Caporali, Christopher D Gregory and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Review
  5. Review
  6. Urinary exosomes as promising biomarkers for early kidney disease detection.American journal of clinical and experimental urology · 2025
    Review
  7. Review
  8. Acute Kidney Injury by Ischemia/Reperfusion and Extracellular Vesicles.International journal of molecular sciences · 2023
    Review
  9. Extracellular Vesicle MicroRNA in the Kidney.Comprehensive Physiology · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. Genes & diseases · 2022
    Article
  14. Epigenetic Modulation of Vasopressin Expression in Health and Disease.International journal of molecular sciences · 2021
    Review
  15. Review
  16. Article
  17. Frontiers in physiology · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Wilna OosthuyzenBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh and.
Kathleen M ScullionBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh and.
Jessica R IvyBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh and.
Emma E MorrisonBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh and.
Robert W HunterBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh and.
Philip J Starkey LewisMedical Research Council Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, Edinburgh, United Kingdom; and.
Eoghan O'DuibhirMedical Research Council Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, Edinburgh, United Kingdom; and.
Jonathan M StreetRenal Diagnostics and Therapeutics Unit, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Andrea CaporaliBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh and.
Christopher D GregoryMedical Research Council Centre for Inflammation Research, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom.
Stuart J ForbesMedical Research Council Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, Edinburgh, United Kingdom; and.
David J WebbBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh and.
Matthew A BaileyBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh and.
James W DearBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh and james.dear@ed.ac.uk.
University of Edinburgh · GBBritish Heart Foundation · GBMRC Centre for Regenerative Medicine · GBCentre for Inflammation Research · GBMedical Research Council · GBNational Institutes of Health · US

Funding

British Heart Foundation FS/11/52/29018Medical Research Council MR/K017047/1Medical Research Council MR/L012766/1
6 · The paper itself

Abstract

Extracellular vesicles (ECVs) facilitate intercellular communication along the nephron, with the potential to change the function of the recipient cell. However, it is not known whether this is a regulated process analogous to other signaling systems. We investigated the potential hormonal regulation of ECV transfer and report that desmopressin, a vasopressin analogue, stimulated the uptake of fluorescently loaded ECVs into a kidney collecting duct cell line (mCCD

Indexed as

AdolescentAnimalsDeamino Arginine VasopressinExtracellular VesiclesHumansKidney Tubules, CollectingMaleMiceRatsVasopressinsDeamino Arginine VasopressinVasopressinsexosomesvasopressinvesicles

Identifiers

PMID27020854
PMCPMC5084879
OpenAlexW2326549848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.