ArticleInternational psychogeriatrics2016
Associations between depression, sleep disturbance, and apolipoprotein E in the development of Alzheimer's disease: dementia.
Article in International psychogeriatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- The Effect of Periodontitis on Dementia and Cognitive Impairment: A Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Depressive Symptoms in the Elderly-An Early Symptom of Dementia? A Systematic Review.Frontiers in pharmacology · 2020Pooled it
- Sleep Disturbance and Cognitive Dysfunction in Multiple Sclerosis: a Systematic Review.Current neurology and neuroscience reports · 2018Pooled it
- Sleep complaints and genetic risk of Alzheimer's disease in older women: associations with memory and tau deposition.The journal of prevention of Alzheimer's disease · 2026Article
- Systematic Review on the Association Between Sleep and the Risk of Alzheimer's Disease: An Evolutionary Perspective.Evolutionary applications · 2026Review
- Brain Structures Associated with Depression in Older Adults in the National Alzheimer's Coordinating Center Uniform Data Set.Journal of geriatric psychiatry and neurology · 2026Article
- Sleep and stress as modifiable drivers of Alzheimer's disease.NPJ dementia · 2026Review
- Depressive Symptoms and Amyloid Pathology.JAMA psychiatry · 2025Article
- Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression.International psychogeriatrics · 2024Article
- Sleep and APOE-ε4 have a synergistic effect on plasma biomarkers and longitudinal cognitive decline in older adults.CNS neuroscience & therapeutics · 2024Article
- Antioxidants and the risk of sleep disorders: results from NHANES and two-sample Mendelian randomization study.Frontiers in nutrition · 2024Article
- Self-reported sleep in relation to risk of dementia a quarter of a century later at age 90+:Behavioral sleep medicine · 2023Article
- Amyloid-β slows cilia movement along the ventricle, impairs fluid flow, and exacerbates its neurotoxicity in explant culture.Scientific reports · 2023Article
- Sleep and substance use: Practice considerations for social workers.Journal of social work practice in the addictions · 2023Article
- Apolipoprotein E ε4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment.Frontiers in aging neuroscience · 2023Article
- Correlations between sleep disturbance and brain structures associated with neurodegeneration in the National Alzheimer's Coordinating Center Uniform Data Set.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022Article
- Association of a History of Sleep Disorder With Risk of Mild Cognitive Impairment and Alzheimer's Disease Dementia.Psychiatry investigation · 2022Article
- Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Association Between Informant-Reported Sleep Disturbance and Incident Dementia: An Analysis of the National Alzheimer's Coordinating Center Uniform Data Set.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022Article
- The Impact of Disease Registries on Advancing Knowledge and Understanding of Dementia Globally.Frontiers in aging neuroscience · 2022Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlzheimer's disease (AD) is a neurodegenerative brain disease that causes cognitive impairment and dementia. Within the US, AD is the most common form of dementia in the elderly, affecting 1 in 10 people over the age of 65. Sleep disturbance has been called a "public health epidemic" and, like depression, is a prodromal symptom of AD but may also contribute to the risk of developing AD. It was hypothesized that sleep disturbance, depression, and the apolipoprotein E (APOE) genotype increase the likelihood of AD.
methodsUtilizing data from the National Alzheimer's Coordinating Center, information from evaluations of 11,453 cognitively asymptomatic participants was analyzed. Survival analysis was used to explore the independent relationships between depression, sleep disturbance, and APOE genotypes with eventual AD diagnosis. Cox proportional hazard models were utilized to explore the main effects and synergistic effects of psychosocial factors as moderated by APOE genotypes.
resultsThis study reinforced the association between APOE and AD. The hazard of developing AD was eight times higher for those with recent depression and the Ɛ4 homozygote (HR = 8.15 [3.70-17.95]). Among Ɛ4 carriers with clinician-verified depression, the hazard was ten times that of the reference group (HR = 10.11 [4.43-23.09]). The hazard for Ɛ4 carriers reporting sleep disturbance was almost 7 times greater than the reference group (HR = 6.79 [2.38-19.37]).
conclusionFindings suggest that sleep disturbance, depression, and APOE Ɛ4 genotype are associated with AD during follow-up evaluations among a group of initially cognitively asymptomatic participants. This study contributes to the literature base exploring an increased hazard or risk of AD due to potential modifiable risk factors as well as genetic biomarkers, such as APOE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.